HCV ANTIGEN POLYPEPTIDE (VARIANTS), SET FOR IMMUNE ANALYSIS, METHOD OF IMMUNE ANALYSIS, POLYNUCLEOTIDE (VARIANTS), POLYNUCLEOTIDE PROBE AND SET CONTAINING THEREOF, METHOD OF HCV DETECTION, METHOD FOR PREPARING HCV-FREE BLOOD (VARIANTS) Russian patent published in 2003 - IPC

FIELD: molecular biology, medicine, immunology. SUBSTANCE: by screening cDNA-libraries nucleotides sequences encoding hepatitis C virus (HCV) polypeptides eliciting antigenic properties are isolated. Invention proposes to use fragments of isolated nucleic acid sequences containing 8 nucleotides, not less, as probes for detection of HCV polynucleotides in biological material and for preparing virus nucleic acid-free blood samples. By method of recombinant DNA antigenic polypeptides of hepatitis C virus and their fragments corresponding to antigenic determinants are prepared. The use of prepared HCV antigens allows to detect the presence of antibodies raised against hepatitis C virus in biological samples and to take blood samples no containing indicated antibodies. Invention can be used in medicine, in part, in diagnosis of hepatitis C. EFFECT: improved method of detection, preparing and analysis, valuable properties. 24 cl, 49 dwg, 17 ex