FIELD: biotechnology, industrial microbiology, amino acids. SUBSTANCE: method involves culturing bacterium of genus Escherichia accumulation of L-lysine in culture and collection of L-lysine from cultural fluid. Microorganism shows activity of dihydropicolinate synthase with its desensibilization by feedback inhibition by L-lysine and aspartate kinase with its desensibilization by feedback inhibition by L-lysine and expression of gene encoding dihydropicolinate reductase is enhanced in cells. Method allows to enhance L-lysine yield by step production. EFFECT: improved preparing method. 9 cl, 24 dwg, 22 tbl, 6 ex
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