FIELD: biotechnology, biochemistry, pharmacy. SUBSTANCE: invention proposes method for preparing human granulocytic colony-stimulating factor (hG-CSF) with milk of transgenic animals. Rabbits with human hybrid gene h-GM-1 that comprises genome copy of gene encoding human granulocytic colony- - stimulating factor and regulatory elements of milk genes directing secretion of protein hG-CSF to milk. Method allows to prepare the purified protein hG-CSF in homogeneous state that is useful for further using in pharmacology and for preparing medicinal formulation of the preparation hG-CSF. EFFECT: improved preparing method, valuable properties of protein factor. 5 cl, 3 dwg, 4 ex
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