OXADIAZOLE DERIVATIVES POSSESSING ANTI-TUMOR EFFECT, MEDICINAL AGENT COMPRISING THEREOF AND METHOD FOR TREATMENT Russian patent published in 2006 - IPC C07D413/12 C07D413/14 A61K31/4245 A61P35/00 A61P35/04

Abstract RU 2275371 C2

FIELD: organic chemistry, medicine, oncology, pharmacy.

SUBSTANCE: invention relates to new sulfonamide derivatives possessing anti-tumor activity, namely to compounds of the formula (I): wherein R⁶ means hydroxyl; R⁷ means methyl, isopropyl, isobutyl, benzyl or indole-3-ylmethyl; R⁸ means hydrogen atom; R⁹ means phenylene; R¹⁰ means thienyl, furyl or pyridyl optionally substituted with lower alkyl or halogen atom. Also, invention relates to their derivatives or pharmaceutically acceptable salts or solvates. Invention describes medicinal agents used in treatment or prophylaxis of cancer and for prophylaxis of metastasis. Also, invention describes a case for treatment of cancer in mammal.

EFFECT: improved treatment method, valuable medicinal properties of agent.

5 cl, 17 tbl, 112 ex

Similar patents RU2275371C2

Title	Year	Author	Number
SULFATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS COMPRISING THEREOF	1997	Vatanabe Fumikhiko Tsuzuki Khiroshige Okhtani Mitsuaki	RU2198656C2
CARBAMOYLUREA DERIVATIVES AND PHARMACEUTICAL COMPOSITION	1995	Sandzi Khagissita Susumu Kamata Jasusi Murakami Nobukhiro Khaga Jasunobu Isikhara Tosiro Konojke	RU2134684C1
ACYLATED HETEROALICYCLIC DERIVATIVES, MEDICINAL AGENT SHOWING SELECTIVE ANTAGONISTIC ACTIVITY AGAINST NK-RECEPTORS, METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENTS	1998	Nisi Takakhide Jamaguti Takesi	RU2174122C1
DERIVATIVES OF SPIROPIPERIDINE, MEDICINAL AGENT, METHOD OF PROPHYLAXIS OR TREATMENT	1999	Nisi Takakhide Jamaguti Takesi Iio Jukiko Takemoto Tosijasu Nakadzima Katsujosi	RU2184735C2
THIENOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION	1994	Suiti Furuja Nobuo Tokh Tetsuja Okhtaki Tosifumi Vatanabe	RU2142275C1
DERIVATIVE OF α-AMINOHYDROXAMIC ACID, METHOD FOR ITS PREPARING AND PHARMACEUTICAL COMPOSITION	2000	Brajtenshtajn Verner Khajaakava Kendzhi Ivasaki Gendzhi Kanazava Takanori Kasaoka Tatsukhiko Koizumi Shinichi Matsunaga Shinichiro Nakadzhima Motovo Sakaki Junichi	RU2265592C2
5-MEMBERED HETEROCYCLIC COMPOUND AND ITS APPLICATION FOR MEDICINAL PURPOSES	2008	Simizu Kazuo Takigava Jasusi Fudzikura Khideki Iizuka Masato Khiratoti Masakhiro Kikuti Norikhiko	RU2515968C2
PYRASOLBENZODIAZEPINES AS CDK2 INHIBITORS, SYNTHESIS INTERMEDIATES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME	2000	Din Tsin'I Lju Dzin'Jun' Mehdison Vinsent Stjuart Pitstsolato Dzhakomo Vehj Chunchehn' Vovkulich Piter Majkl	RU2249593C2
AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED BY CYCLIC GROUP	2008	Tamura Juusuke Suzuki Sindzi Tada Jukio Jonezava Sudzi Fudzikosi Tiaki Matsumoto Sae Koorijama Juudzi Ueno Tatsukhiko	RU2476430C2
METHOD FOR SYNTHESIS OF EPOTHILONE DERIVATIVES, NOVEL EPOTHILONE DERIVATIVES, AS WELL AS NOVEL INTERMEDIATE COMPOUNDS FOR REALISING SAID METHOD AND SYNTHESIS METHODS THEREOF	2003	Kokh Guido Lauzeler Oliv'E	RU2404985C2

RU 2 275 371 C2

Authors

Eshioka Takajuki

Maekava Rjuji

Vatanabe Fumikhiko

Dates

2006-04-27—Published

2001-04-16—Filed