FIELD: organic chemistry, medicine, oncology, pharmacy.
SUBSTANCE: invention relates to new sulfonamide derivatives possessing anti-tumor activity, namely to compounds of the formula (I): wherein R6 means hydroxyl; R7 means methyl, isopropyl, isobutyl, benzyl or indole-3-ylmethyl; R8 means hydrogen atom; R9 means phenylene; R10 means thienyl, furyl or pyridyl optionally substituted with lower alkyl or halogen atom. Also, invention relates to their derivatives or pharmaceutically acceptable salts or solvates. Invention describes medicinal agents used in treatment or prophylaxis of cancer and for prophylaxis of metastasis. Also, invention describes a case for treatment of cancer in mammal.
EFFECT: improved treatment method, valuable medicinal properties of agent.
5 cl, 17 tbl, 112 ex
Title | Year | Author | Number |
---|---|---|---|
SULFATED AMINO ACID DERIVATIVES AND METALLOPROTEINASE INHIBITORS COMPRISING THEREOF | 1997 |
|
RU2198656C2 |
CARBAMOYLUREA DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2134684C1 |
ACYLATED HETEROALICYCLIC DERIVATIVES, MEDICINAL AGENT SHOWING SELECTIVE ANTAGONISTIC ACTIVITY AGAINST NK-RECEPTORS, METHOD OF PROPHYLAXIS OR TREATMENT OF PATIENTS | 1998 |
|
RU2174122C1 |
DERIVATIVES OF SPIROPIPERIDINE, MEDICINAL AGENT, METHOD OF PROPHYLAXIS OR TREATMENT | 1999 |
|
RU2184735C2 |
THIENOPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION | 1994 |
|
RU2142275C1 |
DERIVATIVE OF α-AMINOHYDROXAMIC ACID, METHOD FOR ITS PREPARING AND PHARMACEUTICAL COMPOSITION | 2000 |
|
RU2265592C2 |
5-MEMBERED HETEROCYCLIC COMPOUND AND ITS APPLICATION FOR MEDICINAL PURPOSES | 2008 |
|
RU2515968C2 |
PYRASOLBENZODIAZEPINES AS CDK2 INHIBITORS, SYNTHESIS INTERMEDIATES AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME | 2000 |
|
RU2249593C2 |
AMINODIHYDROTHIAZINE DERIVATIVES SUBSTITUTED BY CYCLIC GROUP | 2008 |
|
RU2476430C2 |
METHOD FOR SYNTHESIS OF EPOTHILONE DERIVATIVES, NOVEL EPOTHILONE DERIVATIVES, AS WELL AS NOVEL INTERMEDIATE COMPOUNDS FOR REALISING SAID METHOD AND SYNTHESIS METHODS THEREOF | 2003 |
|
RU2404985C2 |
Authors
Dates
2006-04-27—Published
2001-04-16—Filed