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2 208 438

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C1

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IPC

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Application

2001134731/14, 2001-12-24

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Start date

2001-12-24

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Actual filing date

2001-12-24

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Published

2003-07-20

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Inventor

Mel'Nikova S.F.Kots A.Ja.Pirogov S.V.Postnikov A.B.Betin V.L.Pjatakova N.V.Grafov M.A.Gavrilova S.A.Seliverstov V.O.Khropov Ju.V.Medvedeva N.A.Severina I.S.Tselinskij I.V.Bulargina T.V.

(73)

Holder

Biologicheskij Fakul'Tet Moskovskogo Gosudarstvennogo Universiteta Im. M.V. Lomonosova

DONOR OF NITROGEN OXIDE ACTIVATING SOLUBLE FORM OF GUANYLATE CYCLASE, INHIBITING PLATELET AGGREGATION AND EXHIBITING SPASMOLYTIC AND VASODILATING EFFECT Russian patent published in 2003 - IPC

Abstract RU 2208438 C1

FIELD: organic chemistry, biochemistry, medicine. SUBSTANCE: invention proposes an agent donor of nitrogen oxide activating soluble form of enzyme guanylate cyclase. Indicated agent inhibits aggregation of platelets, shows spasmolytic and vasodilating agent and it represents 3,6-bis- (4-aminofurazan-3-yl)-1,4,2,5-dioxadiazine of the formula (I) . Invention can be used in clinic as a spasmolytic and vasodilating agent and, in contrast to furoxane, it does not show significant effect on arterial blood pressure that suggests the possibility of its directed local using. EFFECT: valuable medicinal properties of agent. 1 dwg, 9 ex

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RU 2 208 438 C1

Authors

Mel'Nikova S.F.

Kots A.Ja.

Pirogov S.V.

Postnikov A.B.

Betin V.L.

Pjatakova N.V.

Grafov M.A.

Gavrilova S.A.

Seliverstov V.O.

Khropov Ju.V.

Medvedeva N.A.

Severina I.S.

Tselinskij I.V.

Bulargina T.V.

Dates

2003-07-20—Published

2001-12-24—Filed

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