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2 139 932

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C1

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IPC

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Application

98116004/13, 1998-08-21

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Start date

1998-08-21

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Actual filing date

1998-08-21

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Published

1999-10-20

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Inventor

Pirogov S.V.Khropov Ju.V.Kots A.Ja.Ukraintsev K.Eh.Grafov M.A.Davydova M.P.Mel'Nikova S.F.Medvedeva N.A.Tselinskij I.V.Bulargina T.V.

(73)

Holder

Biologicheskij Fakul'Tet Moskovskogo Gosudarstvennogo Universiteta Im.M.V.Lomonosova

DONOR OF NITROGEN OXIDE AND ACTIVATOR OF SOLUBLE FORM OF GUANYLATE CYCLASE Russian patent published in 1999 - IPC

Abstract RU 2139932 C1

FIELD: biochemistry, enzymes. SUBSTANCE: invention relates to the use of benzo[1,2-c:3,4-c':5,6-c'']- -tris[1,2,5]-oxadiazole-1,4,7-trioxide as a donor of nitrogen oxide and an activator of the soluble form of guanylate cyclase. This compound is the more effective donor of nitrogen oxide and shows the more expressed effect on guanylate cyclase soluble form as compared with its structural analog. The use of benzo[1,2-c:3,4-c':5,6-c'']-tris[1,2,5] -oxadiazole-1,4,7- -trioxide of the formula (I) expands the assortment of nitrogen oxide donors and specific agents regulating the activity of the soluble guanylate cyclase. EFFECT: broadened assortment of donors and activators.

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RU 2 139 932 C1

Authors

Pirogov S.V.

Khropov Ju.V.

Kots A.Ja.

Ukraintsev K.Eh.

Grafov M.A.

Davydova M.P.

Mel'Nikova S.F.

Medvedeva N.A.

Tselinskij I.V.

Bulargina T.V.

Dates

1999-10-20—Published

1998-08-21—Filed

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