Patenton — panteon of patents

(19)

RU

(11)

2 240 321

(13)

C2

(51)

IPC

(21) (22)

Application

2002103027/04, 2002-02-07

(24)

Start date

2002-02-07

(22)

Actual filing date

2002-02-07

(45)

Published

2004-11-20

(72)

Inventor

Pirogov S.V.Mel'Nikova S.F.Tselinskij I.V.Romanova T.V.Spiridonova N.P.Betin V.L.Postnikov A.B.Kots A.Ja.Khropov Ju.V.Gavrilova S.A.Grafov M.A.Medvedeva N.A.Pjatakova N.V.Severina I.S.Bulargina T.V.

(73)

Holder

Zao Laboratorii"

DERIVATIVES OF 3,4-BIS-(FURAZAN-3-YL)FUROXANE PRODUCING NITROGEN OXIDE, ACTIVATING GUANYLATE CYCLASE SOLUBLE FORM, INHIBITING PLATELET AGGREGATION AND ELICITING SPASMOLYTIC, VASODILATING, HYPOTENSIVE EFFECT AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2004 - IPC

Abstract RU 2240321 C2

FIELD: organic chemistry, medicine, biochemistry.

SUBSTANCE: invention relates, in particular, new chemical compounds - derivatives of 3,4-bis-(furazan-3-yl)furoxane of the general formula (I):

wherein R = R1 mean hydroxyl group (OH), NH2, N3, lower alkoxyl or group of the general formula: NR2R3 wherein R2 = R3 mean hydrogen atom (H); or R and R3 with nitrogen atom form piperidine ring; or R means NH2 and R1 means (lower alkanoyl)-amino-group under condition that R and R1 don't mean methoxy-group eliciting pharmacological activity. Also, invention describes pharmaceutical compositions based on their base. Claimed compounds are able to generate nitrogen oxide in body, to inhibit aggregation of platelets and to activate the soluble form of guanylate cyclase that provides their spasmolytic, vasodilating and hypotensive effects that allows their applying for prophylaxis and arresting attacks of stenocardia, disorders caused by smooth muscle spasms and for treatment of acute myocardium infarction or acute thrombosis.

EFFECT: valuable medicinal properties of compounds.

3 cl, 4 tbl, 12 dwg, 18 ex

Similar patents RU2240321C2

Title Year Author Number
DONOR OF NITROGEN OXIDE ACTIVATING SOLUBLE FORM OF GUANYLATE CYCLASE, INHIBITING PLATELET AGGREGATION AND EXHIBITING SPASMOLYTIC AND VASODILATING EFFECT 2001
  • Mel'Nikova S.F.
  • Kots A.Ja.
  • Pirogov S.V.
  • Postnikov A.B.
  • Betin V.L.
  • Pjatakova N.V.
  • Grafov M.A.
  • Gavrilova S.A.
  • Seliverstov V.O.
  • Khropov Ju.V.
  • Medvedeva N.A.
  • Severina I.S.
  • Tselinskij I.V.
  • Bulargina T.V.
 RU2208438C1
1,2,5-OXADIAZOLO[3,4-D]PYRIDAZINE-5,6-DIOXIDE DERIVATIVES AS ACTIVATORS OF SOLUBLE FORM OF GUANYLATE-CYCLASE AND AGENTS ACTIVE IN TREATMENT OF CENTRAL NERVOUS SYSTEM, AND COMPOSITIONS BASED ON THESE COMPOUNDS 1997
  • Kots A.Ja.
  • Khropov Ju.V.
  • Grafov M.A.
  • Kulikov A.S.
  • Ovchinnikov I.V.
  • Belushkina N.N.
  • Busygina O.G.
  • Gavrilova S.A.
  • Makhova N.N.
  • Medvedeva N.A.
  • Bulargina T.V.
  • Severina I.S.
 RU2165256C2
INCLUSION COMPLEXES OF DERIVATIVES OF 1,2,5-OXA- -DIAZOLE-2-OXIDE WITH POLYCYCLIC DERIVATIVES OF GLUCOPYRANOSE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION 2001
  • Khropov Ju.V.
  • Kots A.Ja.
  • Postnikov A.B.
  • Bogdanova N.G.
  • Gavrilova S.A.
  • Grafov M.A.
  • Volchkova I.L.
  • Pjatakova N.V.
  • Betin V.L.
  • Kulikov A.S.
  • Ovchinnikov I.V.
  • Zapesochnaja G.G.
  • Matveenko V.N.
  • Makhova N.N.
  • Medvedeva N.A.
  • Severina I.S.
  • Bulargina T.V.
 RU2186782C1
DONOR OF NITROGEN OXIDE AND ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM 1997
  • Ovchinnikov I.V.
  • Khropov Ju.V.
  • Busygina O.G.
  • Kots A.Ja.
  • Ukraintsev K.Eh.
  • Makhova N.N.
  • Bulargina T.V.
  • Severina I.S.
 RU2123046C1
HYPOTENSIVE MEDICATION OF 3-(3-[1,2,4]-TRIAZOLO)-OXATRIAZOLIUM-5-OLATE WITH PROLONGED EFFECT 2007
  • Medvedeva Natalija Aleksandrovna
  • Postnikov Aleksandr Borisovich
  • Artem'Eva Marina Mikhajlovna
  • Medvedev Oleg Stefanovich
  • Shevelev Svjatoslav Arkad'Evich
  • Cherkasova Tat'Jana Ivanovna
  • Dalinger Igor' L'Vovich
 RU2351328C1
SPECIFIC REGULATOR OF ACTIVITY OF NUCLEOTIDE-DEPENDENT ENZYMES 1997
  • Kots A.Ja.
  • Kulikov A.S.
  • Khropov Ju.V.
  • Ovchinnikov I.V.
  • Belushkina N.N.
  • Busygina O.G.
  • Shmal'Gauzen E.V.
  • Jazykova M.Ju.
  • Mast N.V.
  • Jakimova N.G.
  • Lopina O.D.
  • Makhova N.N.
  • Bulargina T.V.
  • Muronets V.I.
  • Severina I.S.
 RU2130490C1
DONOR OF NITROGEN OXIDE AND ACTIVATOR OF SOLUBLE FORM OF GUANYLATE CYCLASE 1998
  • Pirogov S.V.
  • Khropov Ju.V.
  • Kots A.Ja.
  • Ukraintsev K.Eh.
  • Grafov M.A.
  • Davydova M.P.
  • Mel'Nikova S.F.
  • Medvedeva N.A.
  • Tselinskij I.V.
  • Bulargina T.V.
 RU2139932C1
DERIVATIVES OF 1,4,2,5-DIOXADIAZINE 2001
  • Pirogov S.V.
  • Kots A.Ja.
  • Mel'Nikova S.F.
  • Postnikov A.B.
  • Betin V.L.
  • Shmal'Gauzen E.V.
  • Khropov Ju.V.
  • Muronets V.I.
  • Tselinskij I.V.
  • Bulargina T.V.
 RU2212409C1
INHIBITOR OF NO-DEPENDENT ACTIVATION OF SOLUBLE FORM OF GUANYLATE CYCLASE 2001
  • Khropov Ju.V.
  • Pjatakova N.V.
  • Gavrilova S.A.
  • Busygina O.G.
  • Krasnoperov R.A.
  • Medvedeva N.A.
  • Severina I.S.
 RU2189392C1
DERIVATIVES OF TETRAFURAZANO-[3,4-B:3',4'-F:3'',4''-J:3''',- -4'''-N]-[1,4,5,8,9,12,13,16]-OCTAAZABICYCLO-[14,2,2]-EICOSA- -4,8,12-TRIENE AND METHOD OF THEIR SYNTHESIS 2000
  • Sheremetev A.B.
  • Betin V.L.
  • Judin I.L.
  • Kulagina V.O.
  • Khropov Ju.V.
  • Bulargina T.V.
  • Kots A.Ja.
 RU2167161C1

RU 2 240 321 C2

Authors

Pirogov S.V.

Mel'Nikova S.F.

Tselinskij I.V.

Romanova T.V.

Spiridonova N.P.

Betin V.L.

Postnikov A.B.

Kots A.Ja.

Khropov Ju.V.

Gavrilova S.A.

Grafov M.A.

Medvedeva N.A.

Pjatakova N.V.

Severina I.S.

Bulargina T.V.

Dates

2004-11-20—Published

2002-02-07—Filed

download Download PDF read Similar patents