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Application

97122019/13, 1997-12-26

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Actual filing date

1997-12-26

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Published

1999-05-20

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Inventor

Kots A.Ja.Kulikov A.S.Khropov Ju.V.Ovchinnikov I.V.Belushkina N.N.Busygina O.G.Shmal'Gauzen E.V.Jazykova M.Ju.Mast N.V.Jakimova N.G.Lopina O.D.Makhova N.N.Bulargina T.V.Muronets V.I.Severina I.S.

(73)

Holder

Biologicheskij Fakul'Tet Moskovskogo Gosudarstvennogo Universiteta Im.M.V.Lomonosova

SPECIFIC REGULATOR OF ACTIVITY OF NUCLEOTIDE-DEPENDENT ENZYMES Russian patent published in 1999 - IPC

Abstract RU 2130490 C1

FIELD: biochemistry, enzymology. SUBSTANCE: invention can be used for investigation of regulatory mechanism of activity of enzymes - soluble form of guanylate cyclase, glyceraldehyde 3-phosphate dehydrogenase and -adenosine-5'-triphosphatase. Invention involves the use of derivatives of 1,2,5-oxadiazolo- -[3,4-o]pyridazine-5,6-dioxide of the general formula (I) as activators of soluble guanylate cyclase and inhibitors of glyceraldehyde 3-phosphate dehydrogenase and the use of 4,7-dimethyl-1,2,5-oxadiazolo[3,4-o] pyridazine-1,5,6-trioxide as an activator of -ATPase and an inhibitor of alcohol dehydrogenase. Derivatives of 1,2,5-oxadiazolo[3,4-o] pyridazine- -5,6-dioxide of the general formula (I) exhibit regulatory effect on nucleotide-dependent enzyme being more expressed as compared with that in prototype. EFFECT: specific and enhanced activity of compounds proposed. 3 cl, 4 tbl, 11 ex

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RU 2 130 490 C1

Authors

Kots A.Ja.

Kulikov A.S.

Khropov Ju.V.

Ovchinnikov I.V.

Belushkina N.N.

Busygina O.G.

Shmal'Gauzen E.V.

Jazykova M.Ju.

Mast N.V.

Jakimova N.G.

Lopina O.D.

Makhova N.N.

Bulargina T.V.

Muronets V.I.

Severina I.S.

Dates

1999-05-20—Published

1997-12-26—Filed

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