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IPC

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Application

97121604/13, 1997-12-26

(22)

Actual filing date

1997-12-26

(45)

Published

1998-12-10

(72)

Inventor

Ovchinnikov I.V.Khropov Ju.V.Busygina O.G.Kots A.Ja.Ukraintsev K.Eh.Makhova N.N.Bulargina T.V.Severina I.S.

(73)

Holder

Biologicheskij Fakul'Tet Mgu Im.M.V.Lomonosova

DONOR OF NITROGEN OXIDE AND ACTIVATOR OF GUANYLATE CYCLASE SOLUBLE FORM Russian patent published in 1998 - IPC

Abstract RU 2123046 C1

FIELD: biochemistry, enzymology. SUBSTANCE: method involves the use of the known compound - benzo-[1,2- -c:3,4-c']-bis-[1,2,5]-oxadiazole-1,6-dioxide of the formula (I) given in description of invention as a donor of nitrogen oxide and an activator of soluble guanylate cyclase. This compound exhibits the enhanced effectiveness as a donor of nitrogen oxide and shows more expressed activating effect on soluble guanylate cyclase as compared with its structural analog. The proposed compound can be used for study of regulatory effects of nitrogen oxide and mechanism of its action on soluble form of guanylate cyclase and other NO-depending enzymes. EFFECT: broadened pattern of nitrogen oxide donors and specific regulating agents of enzyme. 2 ex

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RU 2 123 046 C1

Authors

Ovchinnikov I.V.

Khropov Ju.V.

Busygina O.G.

Kots A.Ja.

Ukraintsev K.Eh.

Makhova N.N.

Bulargina T.V.

Severina I.S.

Dates

1998-12-10—Published

1997-12-26—Filed

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