DERIVATIVES OF NITRO-ESTERS AND COMPOSITIONS BASED ON THEREOF FOR USING IN CONTROL OF ENURESIS Russian patent published in 2003 - IPC

Abstract RU 2210563 C2

FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to novel compounds that can be used in urinary disturbances. Invention describes derivatives of nitro-esters eliciting pharmacological activity in controlling enuresis and having the general formula: A-X1-NO2 or their salts where A means R(COX)t; t is a whole number from 0 to 1; X mean oxygen atom; R is taken among the following groups: * Group IA: where RII1,RII2,RII3 are similar or different and mean hydrogen atom, linear C1-C6-alkyl or chlorine, fluorine, bromine atom; RII4 means RII1 or bromine atom; RII5 and RII6 man hydrogen atom; X1 means +(CH2-CH2-O)2; * Group IV A): . * Group V A) is taken among the following substances: where RVAc1 is phenyl; X1 in the formula A-X1-NO2 is bivalent binding bridge taken among the following YO- where Y is linear or if possible the branched C1-C20-alkyl comprising from 2 to 5 carbon atoms preferably; where n3 is a whole number from 0 to 3. Invention describes also compositions eliciting pharmacological activity in controlling enuresis and the use of compound of the formula (I) by claim 1 where A means RCOO where R means radical of the formula: where X1 means -(CH2-CH2-O)2-. Compounds are used for treatment of patients with enuresis. Invention provides preparing novel biologically active compounds. EFFECT: valuable medicinal properties of compounds. 6 cl, 8 tbl, 18 ex

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RU 2 210 563 C2

Authors

Del Soldato P'Ero

Sannikolo Franchesko

Dates

2003-08-20Published

1997-09-02Filed