TRICYCLIC CONDENSED HETEROCYCLIC COMPOUNDS, METHOD FOR THEIR PREPARING (VARIANTS) AND PHARMACEUTICAL COMPOSITION Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to tricyclic condensed heterocyclic compounds of the formula (I) wherein X means, for example, CH, CH₂, CHR (wherein R means lower alkyl group or substituted lower alkyl group) or CRR' (wherein R and R' have values indicated above for R); Y means, for example, CH, CH₂ or C=O; z means, for example, sulfur atom, S=O; U means carbon atom, R₁-R₄ mean independently, for example, hydrogen atom, SR (wherein R has above mentioned values), phenyl group, substituted phenyl group, furyl group, thienyl group, benzofuryl or benzothienyl; at least one radical among R₅ and R₈ means hydroxyl group and other radicals R₅ and R₈ mean independently, for example, hydrogen atom. Invention relates also to their optical isomers, conjugates and pharmaceutically acceptable salts. Indicated compounds are characterized by broad spectrum of pharmacological effect, in part, they exhibit relaxing effect on trachea smooth muscles, inhibit allergic response of respiratory ways excellently, inhibit infiltration of inflammatory cells into respiratory ways and, except for, they are harmless. Invention describes also method for preparing compounds, a pharmaceutical composition based on thereof and intermediate compounds of the synthesis. EFFECT: improved preparing method, valuable medicinal properties of compounds. 21 cl, 20 tbl, 184 ex