FIELD: medicine.
SUBSTANCE: group of inventions relates to medicine and aims at treatment of cancer in an individual. It involves introduction to the specified individual of amount of purified heat-shock protein (HSP) preparation. The purified HSP preparation contains purified HSP-peptide complexes containing HSP covalently or non-covalently attached to peptide and where HSP-peptide complexes express antigenicity of said cancer. In addition, an immunogenic reagent is introduced to an individual, where the immunogenic reagent specifically reacts with antigen chosen from the group consisting of VEGF, EGF-R, HER2/NEU, CD25 and CD20, or is being anti-CTLA-4 or anti 41BB antibody.
EFFECT: combined introduction of HSP-peptide complexes and immunogenic reagent allows intensifying immune response in antibody therapy of cancer.
36 cl, 4 ex, 2 dwg
| Title |
Year |
Author |
Number |
| METHOD OF OBTAINING COMPOSITIONS INCLUDING HEAT SHOCK PROTEINS OR ALPHA-2-MACROGLOBULIN, SUITABLE FOR TREATMENT OF MALIGNANT TUMOUR AND INFECTIOUS DISEASE |
2002 |
|
RU2335295C2 |
| USE OF LECTINS FOR GLYCOPROTEIDS AND ANTIGENIC MOLECULES OLIGOMERISATION ACTIVATION |
2004 |
- Zabreki Dzhejms R.
- Monks Stefen A.
|
RU2399381C2 |
| USING HEAT SHOCK PROTEINS FOR IMPROVING THERAPEUTIC EFFECT OF NON-VACCINE THERAPEUTIC INTERVENTION |
2009 |
- Srivastava Pramod K
- Li Tszykhaj
|
RU2573380C2 |
| APPLICATION OF HEAT SHOCK PROTEINS FOR IMPROVEMENT OF THERAPEUTICAL EFFECT OF NON-VACCINAL MEDICINAL EFFECT |
2003 |
- Srivastava Pramod K.
- Li Tszykhaj
|
RU2376029C2 |
| METHOD FOR TREATING INFECTION CAUSED WITH HUMAN PAPILLOMA VIRUS (HPV) |
2001 |
- Nif Dzhon
- Goldstoun Stefen
- Uinnett Mark
- Sidzhel Marvin
- Bu Lesli
|
RU2282461C2 |
| THERAPEUTIC CANCER VACCINE BASED ON STRESS PROTEINS AS IMMUNOGENS |
2014 |
|
RU2694761C2 |
| VACCINE COMPOSITION FOR PROPHYLAXIS AND TREATMENT OF TUMOR DISEASES, RECOMBINANT PLASMID DNA PROVIDING HYBRID PROTEIN SYNTHESIS AND METHOD FOR PRODUCTION THEREOF |
2006 |
- Digtjar' Anton Vasil'Evich
- Lutsenko Elena Valer'Evna
- Lutsenko Sergej Viktorovich
- Pozdnjakova Natal'Ja Vladimirovna
- Severin Evgenij Sergeevich
- Severin Sergej Evgen'Evich
- Solov'Ev Andrej Ivanovich
- Fel'Dman Natalija Borisovna
|
RU2316342C1 |
| VACCINE COMPOSITIONS, METHODS FOR APPLICATION THEREOF IN MELANOMA PREVENTION AND TREATMENT, AND GENETIC CONSTRUCTIONS FOR OBTAINING ACTIVE SUBSTANCES OF COMPOSITION |
2006 |
- Digtjar' Anton Vasil'Evich
- Lutsenko Elena Valer'Evna
- Lutsenko Sergej Viktorovich
- Pozdnjakova Natal'Ja Vladimirovna
- Severin Evgenij Sergeevich
- Severin Sergej Evgen'Evich
- Solov'Ev Andrej Ivanovich
- Fel'Dman Natalija Borisovna
- Khomjakova Anastasija Viktorovna
|
RU2333767C2 |
| PEPTID, OBTAINED FROM HSP70, A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OR PREVENTION OF CANCER, CONTAINING SUCH PEPTID, IMMUNE RESPONSE INDUCTOR AND METHOD FOR OBTAINING ANTIGEN-PRESENTING PATH |
2015 |
- Udaka, Keiko
- Tamada, Koji
- Hazama, Shoichi
- Oka, Masaaki
- Miyakawa, Tomoya
|
RU2684911C2 |
| USE OF HSP70 AS ENZYME ACTIVITY REGULATOR |
2009 |
- Jensen Tomas Kirkegor
- Jotella Mar'Ja Khelena
|
RU2571946C2 |
