FIELD: organic chemistry, biochemistry, medicine, pharmacy. SUBSTANCE: invention relates to derivative of cycloalkene of the formula (Iaa) 
wherein R represents group OR1 wherein R1 is aliphatic hydrocarbon group optionally substituted with such substituents as phenyl, hydroxy-group, alkoxycarbonyl group, carboxyl group; R0 represents hydrogen atom or aliphatic hydrocarbon group; or R and R0 taken in common represent a bond; ring A represents cycloalkene substituted with 1-2 substituents; Ar represents aromatic hydrocarbon group. Invention describes also some variants of method for preparing the claimed compounds, pharmaceutical compositions based on these compounds, method for inhibition of nitrogen oxide and/or cytokine producing. Compounds can be used as therapeutic agent in cardiac diseases, autoimmune diseases and inflammatory diseases. EFFECT: improved preparing method, enhanced effectiveness of inhibition, valuable medicinal properties of compounds. 13 cl, 9 tbl, 93 ex
| Title |
Year |
Author |
Number |
| ANTIHYPERTRIGLYCERIDEMIC COMPOSITION (VARIANTS), METHOD OF ITS PREPARING, METHOD OF TREATMENT OR PROPHYLAXIS OF HYPERTRIGLYCERIDEMIA |
1995 |
- Jasuo Sugijama
- Khidefumi Jukimasa
|
RU2166320C2 |
| AZOLE COMPOUNDS, METHOD OF THEIR SYNTHESIS, ANTIFUNGAL PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF FUNGAL INFECTION |
1998 |
- Itokh Katsumi
- Kitazaki Tomojuki
- Okonogi Kendzi
|
RU2189982C2 |
| TRIAZINE DERIVATIVES, METHODS OF THEIR SYNTHESIS, ANTIPROTOZOAN COMPOSITION, ADDITION TO ANIMAL FOOD, METHOD OF INHIBITION OF PROTOZOAN INFECTION IN ANIMALS |
1994 |
- Khideki Miki
- Koiti Ivanaga
- Tosimi Matsuno
|
RU2146674C1 |
| CYCLIC ETHER, METHODS OF ITS SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF SODIUM CHANNEL MODULATION |
1997 |
- Okhkava Sigenori
- Khasimoto Tadatosi
- Fukatsu Kokhdzi
|
RU2173686C2 |
| DERIVATIVES OF 5-PYRIDYL-1,3-AZOLE, METHOD FOR THEIR PREPARING, THEIR PRODRUG, PHARMACEUTICAL COMPOSITION, METHOD FOR ANTAGONISM OF ADENOSINE A3-RECEPTOR, METHOD FOR INHIBITION OF P38 MAP KINASE, METHOD FOR INHIBITION PRODUCING TNF-ALPHA AND METHOD FOR PROPHYLAXIS |
2000 |
- Okhkava Sigenori
- Kanzaki Naojuki
- Mivatasi Sejdzi
|
RU2237062C2 |
| DERIVATIVES OF AZOLE, METHODS OF THEIR SYNTHESIS AND ANTIFUNGAL AGENT |
1994 |
- Katsumi Iton
- Kendzi Okonogi
- Akikhiro Tasaka
|
RU2131417C1 |
| HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, METHOD OF ANTAGONISM OF ANGIOTENSIN-II |
1992 |
- Takekhiko Naka
- Esijuki F. Inada
|
RU2168510C2 |
| DERIVATIVES OF PYRIDOPYRIMIDINE, THEIR SYNTHESIS, A PHARMACEUTICAL COMPOSITION, A METHOD OF TREATMENT |
1993 |
- Suiti Furujja
- Tetsujja Okhtaki
|
RU2127734C1 |
| DERIVATIVES OF 2,4-OXAZOLIDINEDIONE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALT, METHODS OF SYNTHESIS, MEDICINAL COMPOSITION SHOWING HYPOGLYCAEMIC AND HYPOLIPIDEMIC EFFECT, METHOD OF BLOOD GLUCOSE AND LIPID CONTENT DECREASE IN MAMMALIAN WITH DIABETES MELLITUS OR HYPERLIPIDEMIA |
1994 |
- Takasi Sokhda
- Khitosi Ikeda
- Ju Momose
- Satiko Imai
|
RU2126797C1 |
| DERIVATIVES OF OXAZOLIDINEDIONE, THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1995 |
- Takasi Sokhda
- Khirojuki Odaka
- Jju Momoze
- Mitsuru Kavada
|
RU2144030C1 |
