METHOD FOR CONVERSION OF 9-DIHYDRO-13-ACETYLBACCATIN III TO TAXOL AND ITS DERIVATIVES Russian patent published in 2003 - IPC

Abstract RU 2216544 C2

FIELD: organic chemistry, chemical technology, antibiotic. SUBSTANCE: invention relates to the novel method for preparing taxol, it analogues and their intermediate compound. Method involves stages for protection of hydroxy-group at C-7-position of 9-dihydro-13-deacetylbaccatine III with suitable protecting group; oxidation of hydroxy-group at position C-9 and addition of suitable side chain to position C-13. Intermediate compounds involve compounds of the formula (I) and formula (II) wherein R is taken among the group consisting of benzyl, substituted benzyl, tosyl, substituted tosyl, methoxymethyl, benzoyl and substituted benzoyl. Invention provides the development of the novel method for preparing taxol. EFFECT: improved preparing method. 16 cl, 1 tbl

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RU 2 216 544 C2

Authors

Liu Dzhian

Dates

2003-11-20Published

1998-05-01Filed