THIAZOLE DERIVATIVES, METHOD FOR PREPARING AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2003 - IPC

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to novel thiazole derivatives of the formula (I) wherein R¹ means (a) , (b) or (c) ; R² means (II) ; R³ means hydrogen atom, lower alkyl; R⁴ means phenyl; R⁵-R⁸ mean hydrogen atom; R⁹ means hydrogen atom; R¹⁰ means hydrogen atom, phenyl; A means oxygen atom, -CH=CH- and so on; arylene represents phenylene or substituted phenylene where substituents are taken among alkoxy-group and so on; symbols from a to f = 0 or mean whole positive figures, and so on; and to their pharmaceutically acceptable salts and esters. Invention relates also to method for preparing compound of the formula (I) by interaction of compound of the formula (XVIII) with amine of the formula (XIX) . Invention relates also to pharmaceutical composition eliciting effect of antagonist of vitronectin receptor and containing compound of the formula (I) as an active substance and therapeutically inert carrier. Invention provides preparing novel compounds eliciting effect of antagonist of vitronectin receptor. EFFECT: improved preparing method, valuable medicinal properties of compounds. 15 cl, 1 tbl, 21 ex