FIELD: organic chemistry, natural compounds, pharmacy. SUBSTANCE: invention relates to tetracyclic analogues of camptothecins of the formula (I) 
wherein R1,R2,R3,R4,R5,R10 are given in the invention claim. Invention describes also intermediate compounds and pharmaceutical composition used for inhibition of topoisomerase=I and II activity. Invention can be used in medicine as a therapeutic agent for treatment of cancer diseases. Invention provides preparing new compounds eliciting valuable pharmacological properties. EFFECT: improved preparing methods, valuable medicinal properties of compounds. 16 cl, 2 tbl, 14 ex
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