NEW DERIVATIVES OF AMIDINES, THEIR PREPARING AND USING AS MEDICINAL AGENTS Russian patent published in 2006 - IPC C07D333/26 A61K31/381 A61P25/00

Abstract RU 2272807 C2

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to new derivatives of amidines of the general formula (I):

wherein R¹ means alkyl; R² means alkyl, alkenyl, alkynyl or cyanoalkyl; R³ means hydrogen atom; n = 0 or 1; X means -(CH₂)_m- wherein m = 0 or 1; A means heterocyclic 5-membered aryl radical comprising sulfur atom (S), or to salts of these compounds, their preparing and using as medicinal agents. Also, invention relates to using abovementioned derivatives for preparing a medicinal agent designated for inhibition of activity of NO-synthases (NOS) and/or monoaminoxidases (MAO).

EFFECT: improved preparing method, valuable medicinal properties of compounds.

6 cl, 5 ex

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RU 2 272 807 C2

Authors

Shabrie De Lasson'Er P'Er-Eht'Enn

Kharnett Dzheremia

Dates

2006-03-27—Published

2000-11-15—Filed