FIELD: biotechnology, genetic engineering, medicine, pharmacy.
SUBSTANCE: polypeptide able to bind with intracellular domain of Fas-R is prepared by culturing cells transformed with vector comprising the DNA sequence encoding indicated polypeptide. The modulation of effect of Fas-R ligand is carried out using polypeptide or mRNA encoding polypeptide. Pharmaceutical composition used for modulation of effect of Fas-R ligand on cells comprises indicated polypeptide or viral vector encoding its. Invention provides carrying out the development of therapeutic agents for modulation of cytotoxic activity. Invention can be used for preparing protein able to modulate function of Fas-receptor.
EFFECT: improved isolating and identifying method, valuable biological and medicinal properties of DNA, polypeptide and composition.
12 cl, 11 dwg, 1 ex
| Title |
Year |
Author |
Number |
| DNA SEQUENCE ENCODING POLYPEPTIDE THAT BINDS WITH MORT-1 (VARIANTS), POLYPEPTIDE (VARIANTS) AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR MODULATING LIGAND FAS-R OR TNF EFFECT ON CELLS (VARIANTS), METHOD FOR TREATMENT OF CELLS, METHOD FOR ISOLATION AND IDENTIFICATION OF PROTEINS, METHOD FOR MODULATING MORT-1-INDUCED EFFECT OR MORT-1-BINDING PROTEIN-INDUCED EFFECT ON CELLS |
1996 |
- Vollakh Dehvid
- Boldin Mark
- Goncharov Tanja
- Gol'Tsev Jurij
|
RU2235779C2 |
| POLYPEPTIDE POSSESSING CAPACITY FOR BINDING WITH INTRACELLULAR DOMAIN p-55 OF TNF-RECEPTOR, DNA MOLECULE ENCODING THIS POLYPEPTIDE, EXPRESSION VECTOR AND METHOD FOR PREPARING POLYPEPTIDE |
1995 |
- Vallakh David
- Boldin Mark
- Mett Igor'
- Varfolomeev Evgenij
|
RU2273664C2 |
| POLYPEPTIDE-LIGAND FLT3 (VARIANTS), POLYNUCLEOTIDE (VARIANTS), EXPRESSING VECTOR (VARIANTS), STRAIN OF CELL CHO (VARIANTS), METHOD FOR PRODUCING POLYPEPTIDE-LIGAND FLT3 (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) |
1994 |
- Lajmehn Stjuart D.
- Bekmann M. Patritsija
|
RU2220979C2 |
| LIGAND GITR AND MOLECULES AND ANTIBODIES BOUND WITH LIGAND GITR, AND VERSIONS OF THEIR APPLICATION |
2004 |
- Kollinz Mehri
- Shevach Ehtan Menakhem
- Makkh'Ju Rebekka S'Juzn
- Uitters Mehtt'Ju Dzhejms
- Jang Debora Ehnn
- Birn Majkl Chehpmen
- Reddi Padmalata F.
- Stefenz Dzhoffri Lorens
- Karreno Beatriz M.
|
RU2369636C2 |
| ISOLATED NUCLEIC ACID MOLECULE ENCODING CHIMERIC TIE-2-LIGAND (VARIANTS), CHIMERIC OR MODIFIED TIE-2-LIGAND AND METHOD FOR ITS PREPARING, VECTOR, METHOD FOR PREPARING SYSTEM VECTOR-HOST, CONJUGATE, PHARMACEUTICAL COMPOSITION |
1997 |
- Dehvis Sehmjuel'
- Jankopoulos Dzhordzh D.
|
RU2233880C2 |
| CONDITIONALLY ACTIVE CHIMERIC ANTIGEN RECEPTORS FOR MODIFIED T-CELLS |
2015 |
|
RU2764074C2 |
| METHOD OF HETEROLOGICAL POLYPEPTIDE PURIFICATION |
2004 |
- Lester Filip M.
- Persson Dzhozefin
|
RU2337968C2 |
| CONDITIONALLY ACTIVE CHIMERIC ANTIGENIC RECEPTORS FOR MODIFIED T CELLS |
2016 |
|
RU2759957C2 |
| APOPTOSIS DETECTION TECHNIQUES AND REAGENTS |
2007 |
- Ostin Kehri D.
- Lorens Dehvid A.
- Ashkenazi Avi
|
RU2450273C2 |
| METHOD OF PRODUCING POLYPEPTIDES |
2005 |
- Vun-Lehm S'Juzn Leung
- Shvarts Dzhehjms R.
|
RU2433185C2 |
