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2 222 546

(13)

(51)

IPC

(21) (22)

Application

2001107841/04, 1999-08-11

(24)

Start date

1999-08-11

(22)

Actual filing date

1999-08-11

(45)

Published

2004-01-27

(72)

Inventor

Zifers VernerBikker RikhardDesh DiterFon Ehjsmondt JorgKeller Rajnkhol'DRikhard Frank

(73)

Holder

Aventis Farma Dojchland Gmbkh

METHOD FOR PURIFICATION OF INSULIN BY CHROMATOGRAPHY METHOD Russian patent published in 2004 - IPC

Abstract RU 2222546 C2

FIELD: biochemistry, proteins, hormones. SUBSTANCE: invention relates to method for purification of insulin by chromatography method. Mobile phase comprises at least one water-mixable organic solvent and at least one buffer substance with pH value from 7 to 11. Stationary phase represents pressure-stable organic polymeric chromatography material with average particles size from 10 to 50 mcm. Method provides the enhancement degree of insulin separation and reduced number of stages in purification process. EFFECT: improved purification method. 17 cl, 5 tbl, 4 ex

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RU 2 222 546 C2

Authors

Zifers Verner

Bikker Rikhard

Desh Diter

Fon Ehjsmondt Jorg

Keller Rajnkhol'D

Rikhard Frank

Dates

2004-01-27—Published

1999-08-11—Filed