FIELD: microbiology, biotechnology. SUBSTANCE: method for preparing biological stimulating agent with the probiotic immunostimulating effect involves direct concentrating microorganism culture suspension and ultrafiltrate stabilization by thermal treatment at 80-110 C for 15-30 min. Proposed method allows simultaneous preparing the concentrate of bacterial suspension for producing probiotic medicinal forms based on live microorganisms and cell-free biological stimulating agent with broad spectrum effect in vivo (prophylaxis and treatment of dysbacteriosis and immunodeficiency states) and in vitro (stimulating supplement to nutrient media). Invention can be used in producing probiotic preparations. EFFECT: improved preparing method. 2 tbl, 3 ex
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