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Application

2002127066/04, 2002-10-11

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Start date

2002-10-11

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Actual filing date

2002-10-11

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Published

2004-06-27

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Inventor

Filippova O.V.Peresada V.P.Likhosherstov A.M.Kryzhanovskij S.A.Vititnova M.B.Kaverina N.V.Reznikov K.M.

(73)

Holder

Filippova Ol'Ga Vsevolodovna

1-(2,4,6-TRIMETHYLPHENYL)-2-[(2'-HYDROXY-3'-PHENYLOXY)-N-SUBSTITUTED-AMINOMETHYL]-PYRROLES AND THEIR SALTS ELICITING ANTI-ARRHYTHMIC AND ANTI-ISCHEMIC ACTIVITY Russian patent published in 2004 - IPC

Abstract RU 2231525 C1

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a new group of pyrroles, in particular, to 1-(2,4,6-trimethylphenyl)-2-[(2'-hydroxy-3'-phenyloxy)-N-substituted-aminimethyl]-pyrroles of the general formula:

wherein (VI): R means hydrogen atom; (VIa): R means -C(O)H; (VIIb): R means -C(O)CH₃; (VIIIa): R means -CH₃; (VIIIb): R means -C₂H₅, and to their pharmaceutically acceptable dicarboxylic acid salts that elicit anti-arrhythmic and anti-ischemic activity. The intensity of their effect exceeds that of verapamil, amiodarone and lidocaine used in clinics.

EFFECT: valuable medicinal properties of compounds.

7 tbl, 6 ex

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RU 2 231 525 C1

Authors

Filippova O.V.

Peresada V.P.

Likhosherstov A.M.

Kryzhanovskij S.A.

Vititnova M.B.

Kaverina N.V.

Reznikov K.M.

Dates

2004-06-27—Published

2002-10-11—Filed