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2 775 616

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IPC

A61K31/195(2006-01-01)

A61P9/06(2006-01-01)

(21) (22)

Application

2020143085, 2020-12-25

(24)

Start date

2020-12-25

(22)

Actual filing date

2020-12-25

(45)

Published

2022-07-05

(72)

Inventor

Borisova Nadezhda YurevnaAfanaseva Elena YulevnaBorisova Elena YakovlevnaArzamastsev Evgenij VeniaminovichEgorov Oleg SergeevichKrylov Aleksandr VladimirovichAsilova Nina YurevnaZubin Evgenij MikhajlovichKaldyrkaeva Olga SergeevnaTerekhova Olga AleksandrovnaLevitskaya Elena LeonidovnaKudryavtseva Elvira ValerevnaPoluektova Valentina PetrovnaGajsinyuk Tatyana VladimirovnaAmbartsumyan Arega Shmavonovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Obrazovatelnoe Uchrezhdenie Vysshego Obrazovaniya Rossijskij Tekhnologicheskij Universitet"Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Meditsinskij Issledovatelskij Tsentr Kardiologii» Ministerstva Zdravookhraneniya Rossijskoj Federatsii Kardiologii» Minzdrava Rossii)

2-(2-(DIALKYLAMINO POLYETHOXY))ETHYL CARBOXYLATES AND HYDROCHLORIDES THEREOF WITH ANTIARRHYTHMIC ACTIVITY AND PHARMACEUTICAL COMPOSITIONS BASED THEREON Russian patent published in 2022 - IPC A61K31/195 A61P9/06

Abstract RU 2775616 C2

FIELD: pharmaceuticals.

SUBSTANCE: invention relates to the field of pharmacology and pertains to the creation of new medicinal products for preventing and treating cardiac arrhythmias. Invention relates to compounds exhibiting antiarrhythmic activity and represented by the general formula (I) wherein when n=1 and NR₂=NEt₂, then R’=Ph; PhCH₂; PhOCH₂; 2,4-Cl₂C₆H₃OCH₂; when n=1 and NR₂=NC₅H₁₀, then R’=Ph; PhCH₂; PhOCH₂; 2,4-Cl₂C₆H₃OCH₂; when n=1 and NR₂=NC₄H₈O, then R’=Ph; PhOCH₂; 2,4-Cl₂C₆H₃OCH₂; when n=2 and NR ₂=NC₅H₁₀, then R’=Ph; PhOCH₂; 2,4-Cl₂C₆H₃OCH₂; when n=2 and NR₂=N C₄H₈O, then R’=Ph; PhOCH₂; 2,4-Cl₂C₆H₃OCH₂; when n=3 and NR₂=NC₅H₁₀, then R’= PhOCH₂; 2,4-Cl₂C₆H₃OCH₂ (wherein NC₄H₈O is morpholino and NC₅H₁₀ is piperidino). Invention also relates to a medicinal product and pharmaceutical composition including said compounds.

EFFECT: production of compounds applicable in preventing and treating cardiac arrhythmias.

(I)

3 cl, 3 dwg, 4 tbl, 30 ex

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RU 2 775 616 C2

Authors

Borisova Nadezhda Yurevna

Afanaseva Elena Yulevna

Borisova Elena Yakovlevna

Arzamastsev Evgenij Veniaminovich

Egorov Oleg Sergeevich

Krylov Aleksandr Vladimirovich

Asilova Nina Yurevna

Zubin Evgenij Mikhajlovich

Kaldyrkaeva Olga Sergeevna

Terekhova Olga Aleksandrovna

Levitskaya Elena Leonidovna

Kudryavtseva Elvira Valerevna

Poluektova Valentina Petrovna

Gajsinyuk Tatyana Vladimirovna

Ambartsumyan Arega Shmavonovna

Dates

2022-07-05—Published

2020-12-25—Filed