METHOD FOR MILLING AND PRODUCING OF FINELY-DISPERSED MEDICINAL SUBSTANCES Russian patent published in 2004 - IPC

FIELD: milling equipment for producing of finely-dispersed substances used as inhalation medicinal drugs.

SUBSTANCE: method involves milling crystalline substance by atomizing thereof with the use of milling medium including helium having temperature within the range of from -30⁰C to -120⁰C. Helium may be used as milling medium. Crystalline substance may include powdered medicinal drug, for example, crystalline substance may be triamcinolone acetonide. Milled product may comprise amorphous phase content below 5%. Milled product may comprise amorphous phase content below 2% or below 1%. Milled product may include powdered medicinal drug adapted for inhalation, with average particle size of milled product being less than 10 microns. Crystalline substance is substantially free from amorphous phase, has average particle size of 1 micron, and may be triamcinolone acetonide.

EFFECT: increased efficiency in producing of finely-dispersed substance from crystalline substance.

11 cl