BIS(METOXYBENZYLAMINOALKYL)AMINES WITH CARDIOTROPIC ACTIVITY Russian patent published in 2017 - IPC C07C211/27 A61P9/10 

FIELD: pharmacology.

SUBSTANCE: invention relates to new bis(methoxybenzylaminoalkyl)amines of general formula (I) and their physiologically acceptable salts with cardiotropic activity. Due to their acute toxicity (LD₅₀), compounds belong to classes III and IV of toxicity. In the general formula (I), R₁, R₂, R₃, R₄ may be two or three hydrogens, or one or two methoxy groups, n and m may be the same and have the values 2 or 3 or different and have the values n=2 and m=3. As the pharmaceutically acceptable salts of bis(methoxybenzylaminoalkyl)amines of general formula I, their trihydrochlorides of general formula II (I⋅3HCl) are preferred. Most preferred are trihydrochlorides selected from trihydrochloride N¹-(2,5-dimethoxybenzyl)-N²-{2-[(2,5-dimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (IIc), trihydrochloride N¹-(2,3,4-trimethoxybenzyl)-N²-{2-[(2,3,4-trimethoxybenzyl)amino]ethyl}-1,2-ethanediamine (IId) and trihydrochloride N¹-(2,4-dimethoxybenzyl)-N³-{3-[(2,4-dimethoxybenzyl)amino]-propyl}-1,3-propanediamine (IIf).

EFFECT: compounds exhibit anti-ischemic and antiarrhythmic, in particular antifibrillatory, action.

14 cl, 5 tbl, 14 ex