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2 813 348

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IPC

C07C213/08(2006-01-01)

C07C217/10(2006-01-01)

C07C319/20(2006-01-01)

C07C323/29(2006-01-01)

A61K31/137(2006-01-01)

A61K31/145(2006-01-01)

A61P9/00(2006-01-01)

A61P9/06(2006-01-01)

A61P9/10(2006-01-01)

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Application

2023111849, 2023-05-05

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Start date

2023-05-05

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Actual filing date

2023-05-05

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Published

2024-02-12

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Inventor

Mokrov Grigorij VladimirovichBarchukov Vladimir ValerevichBarchukova Elena IgorevnaKryzhanovskij Sergej AleksandrovichStolyaruk Valerij NikolaevichVititnova Marina BorisovnaTsorin Iosif BorisovichGudasheva Tatyana Aleksandrovna

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Nauchnoe Uchrezhdenie Issledovatelskij Tsentr Originalnykh I Perspektivnykh Biomeditsinskikh I Farmatsevticheskikh Tekhnologij"

2,2'-HYDROXY- AND 2,2'-THIO-BIS(N-(2,3,4-TRIMETHOXYBENZYL)ETHAN-1-AMINES) WITH CARDIOTROPIC ACTIVITY Russian patent published in 2024 - IPC C07C213/08 C07C217/10 C07C319/20 C07C323/29 A61K31/137 A61K31/145 A61P9/00 A61P9/06 A61P9/10

Abstract RU 2813348 C1

FIELD: biologically active compounds.

SUBSTANCE: invention relates to 2,2'-oxy- and 2.2'-thio-bis(N-(2,3,4-trimethoxybenzyl)ethan-1-amines) of general formula I, where X can be oxygen or sulphur atoms, as well as physiologically acceptable salts of compounds I of general formula I * 2HA (II), where HA are organic and inorganic physiologically acceptable acids. In addition, the invention relates to individual compounds dihydrochloride 2,2'-oxybis(N-(2,3,4-trimethoxybenzyl)ethan-1-amine) (IIa, ALM-863) and dihydrochloride 2,2'-thiobis(N-(2,3,4-trimethoxybenzyl)ethan-1-amine) (IIb, ALM-867), as well as to the method of treating cardiovascular diseases by administering effective amounts of compounds of general formula I or their physiologically acceptable salts.

EFFECT: production of new compounds of general formula I and their salts having cardiotropic activity.

5 cl, 1 dwg, 4 tbl, 6 ex

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RU 2 813 348 C1

Authors

Mokrov Grigorij Vladimirovich

Barchukov Vladimir Valerevich

Barchukova Elena Igorevna

Kryzhanovskij Sergej Aleksandrovich

Stolyaruk Valerij Nikolaevich

Vititnova Marina Borisovna

Tsorin Iosif Borisovich

Gudasheva Tatyana Aleksandrovna

Dates

2024-02-12—Published

2023-05-05—Filed