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Application

2000106709/13, 2000-03-20

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Start date

2000-03-20

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Actual filing date

2000-03-20

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Published

2002-02-27

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Inventor

Tumanova O.Ju.Kuvshinov V.N.Melamed N.V.Ushakova T.A.Masharskij A.Eh.Il'Ichev A.A.Klimov N.A.Kozlov A.P.Sandakhchiev L.S.

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Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I BiotekhnologiiAvtonomnaja Nekommercheskaja Organizatsija Tsentr"

PEPTIDE-SIMULATOR OF HUMAN IMMUNODEFICIENCY TYPE-1 VIRUS PROTEIN GP41 CONSERVATIVE EPITOPE RECOGNIZED BY VIRUS-NEUTRALIZING MONOCLONAL ANTIBODY 2F5 (VARIANTS) Russian patent published in 2002 - IPC

Abstract RU 2179980 C2

FIELD: biotechnology, virology, vaccines. SUBSTANCE: invention describes 12 peptide- simulators of human immunodeficiency type-1 virus protein gp41 conservative epitope prepared by affinity selection from phage peptide libraries. These peptides differ from HIV-1 protein gp41 conservative epitope by amino acid sequence but retain ability to bind with virus-neutralizing monoclonal antibodies 2F5. Invention ensures to obtain high-effective vaccine against HIV based on peptides indicated. Invention can be used in development of effective vaccine preparations against AIDS. EFFECT: enhanced effectiveness of vaccine, valuable medicinal properties. 12 cl, 3 dwg, 2 ex

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RU 2 179 980 C2

Authors

Tumanova O.Ju.

Kuvshinov V.N.

Melamed N.V.

Ushakova T.A.

Masharskij A.Eh.

Il'Ichev A.A.

Klimov N.A.

Kozlov A.P.

Sandakhchiev L.S.

Dates

2002-02-27—Published

2000-03-20—Filed