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IPC

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Application

2000121342/13, 2000-08-09

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Start date

2000-08-09

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Actual filing date

2000-08-09

(45)

Published

2002-07-10

(72)

Inventor

Tumanova O.Ju.Kuvshinov V.N.Nekrasov B.G.Mikhajlova V.K.Il'Ichev A.A.Sandakhchiev L.S.

(73)

Holder

Gosudarstvennyj Nauchnyj Tsentr Virusologii I Biotekhnologii

PEPTIDE-SIMULATOR OF PROTEIN GP120 HIV-1 EPITOPE Russian patent published in 2002 - IPC

Abstract RU 2184780 C2

FIELD: biotechnology, genetic and protein engineering. SUBSTANCE: invention relates to preparing peptide-simulators of an antigenic determinant of protein gp120 of human immunodeficiency virus type-1, HIV-1, using phage display that is recognized by virus-neutralizing monoclonal antibodies 2G12. Peptides simulating a full-sized glycoprotein gp120 are obtained by method of affinity selection based on binding with virus-neutralizing antibodies 2G12. Peptides are exposed on surface of filamentous bacteriophages in composition of "minor" envelope protein pIII being each phage particle comprises 5 copies of a single peptide. EFFECT: improved method of peptides preparing. 4 dwg, 2 ex

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RU 2 184 780 C2

Authors

Tumanova O.Ju.

Kuvshinov V.N.

Nekrasov B.G.

Mikhajlova V.K.

Il'Ichev A.A.

Sandakhchiev L.S.

Dates

2002-07-10—Published

2000-08-09—Filed