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IPC

A61K39/12(2006-01-01)

A61P37/04(2006-01-01)

C12N15/70(2006-01-01)

C12N15/117(2010-01-01)

C12N15/49(2006-01-01)

(21) (22)

Application

2016151969, 2016-12-27

(24)

Start date

2016-12-27

(22)

Actual filing date

2016-12-27

(45)

Published

2018-01-24

(72)

Inventor

Chikaev Anton NikolaevichKarpenko Larisa IvanovnaRudometov Andrej PavlovichAndreeva Nadezhda BorisovnaIlichev Aleksandr AlekseevichShcherbakova Nadezhda Sergeevna

(73)

Holder

Federalnoe Byudzhetnoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Federalnoj Sluzhby Po Nadzoru V Sfere Zashchity Prav Potrebitelej I Blagopoluchiya Cheloveka Gnts Vb Rospotrebnadzora)

RECOMBINANT CHIMERICAL nTBI POLYPEPTIDE-IMMUNOGEN WITH ABILITY TO INDUCE NEUTRALIZING ANTIBODIES TO TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS AND INTENDED FOR USE AS COMPONENT OF VACCINE AGAINST HIV-1 Russian patent published in 2018 - IPC A61K39/12 A61P37/04 C12N15/70 C12N15/117 C12N15/49

Abstract RU 2642258 C1

FIELD: medicine.

SUBSTANCE: recombinant chimerical polypeptide-immunogen is proposed, including conservative T- and B-cell epitopes of HIV-1 and consecutive peptide fragments of p24, gp41, gp120 proteins, recognizable by wide-neutralizing 10e8, 2F5, VRC01 antibodies.

EFFECT: improved HIV-specific immune response due to the inclusion of unique linear conformational epitopes imitators, recognizable by wide-neutralizing antibodies into the polypeptide-immunogen nTBI.

6 dwg, 5 ex

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RU 2 642 258 C1

Authors

Chikaev Anton Nikolaevich

Karpenko Larisa Ivanovna

Rudometov Andrej Pavlovich

Andreeva Nadezhda Borisovna

Ilichev Aleksandr Alekseevich

Shcherbakova Nadezhda Sergeevna

Dates

2018-01-24—Published

2016-12-27—Filed