VIRAL REPLICATION INHIBITORS, METHOD FOR PRODUCTION THEREOF AND THERAPEUTIC APPLICATIONS THEREOF Russian patent published in 2019 - IPC C07D405/10 C07D311/04 C07D491/52 A61P31/18 A61K31/353 

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds selected from the group: 2-(tert-butoxy)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetic acid; 2-(tert-butoxy)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]acetic acid; 2-(tert-butoxy)-2-[3-(cyclopentyl)-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-(trifluoromethyl)phenyl]acetic acid; 2-(tert-butoxy)-2-(6-cyclopropyl-4'-methoxy-3-methyl-biphenyl-2-yl]acetic acid; (S)-2-(tert-butoxy)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]acetic acid; 2-(tert-butoxy)-2-(6-cyclopropyl-3,4'-dimethyl-biphenyl-2-yl)acetic acid; 2-(tert-butoxy)-2-(6-cyclopropyl-4'-fluoro-3-methyl-biphenyl-2-yl)acetic acid; 2-(tert-butoxy)-2-[3-cyclopropyl-6-methyl-2-(5-methyl-chroman-6-yl)phenyl]acetic acid; (trans-3-bicyclopropyl-2-yl-2-chroman-6-yl-6-methyl-phenyl)tert-butoxy-acetic acid; 2-(tert-butoxy)-2-[3-cyclopropyl-2-(4,4-dimethyl-cyclohex-1-enyl)-6-methyl-phenyl]acetic acid; 2-(2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-2-ethoxy-acetic acid; 2-(tert-butoxy)-2-(4'-chloro-6-cyclopropyl-3-methyl-biphenyl-2-yl)acetic acid; tert-butoxy-[3-cyclopropyl-2-(8-fluoro-5-methyl-chroman-6-yl)-6-methyl-phenyl]-acetic acid; 2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-cyclopropoxy-acetic acid; (S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-2-cyclopropoxy-acetic acid; tert-butoxy-[2-chroman-6-yl-6-methyl-3-(1-methyl-cyclopropyl)-phenyl]-acetic acid; tert-butoxy-[2-chroman-6-yl-6-methyl-3-(cis-2-methyl-cyclopropyl)-phenyl]acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-trifluoromethyl-phenyl)-cyclopropoxy-acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-propoxy-acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)cyclopropyl-methoxy-acetic acid; cyclopropoxy-[3-cyclopropyl-6-methyl-2-(5-methyl-chroman-6-yl)phenyl]acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-cyclobutoxy-acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-(2,2-difluoro-ethoxy)acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)isopropoxy-acetic acid; cyclopropoxy-[3-cyclopropyl-2-(8-fluoro-5-methyl-chroman-6-yl)-6-methyl-phenyl]acetic acid; (S)-tert-butoxy-[3-cyclopropyl-6-methyl-2-(5-methyl-chroman-6-yl)phenyl]acetic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-(1-methyl-cyclopropoxy)acetic acid; (S)-cyclopropoxy-[3-cyclopropyl-6-methyl-2-(5-methyl-chroman-6-yl)phenyl]acetic acid; (S)-tert-butoxy-[3-cyclopropyl-2-(8-fluoro-5-methyl-chroman-6-yl)-6-methyl-phenyl]acetic acid; tert-butoxy-(6-chroman-6-yl-7-cyclopropyl-quinolin-5-yl)acetic acid; tert-butoxy-(2-chroman-6-yl-3-cyclobutyl-6-methyl-phenyl)acetic acid; (S)-cyclopropoxy-[3-cyclopropyl-2-(8-fluoro-5-methyl-chroman-6-yl)-6-methyl-phenyl]acetic acid; 3-cyclopropyl-2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]propanoic acid; 2-[3-cyclopropyl-2-(3,4-dihydro-2H-1-benzopyran-6-yl)-6-methylphenyl]-4-methylpentanoic acid; (2-chroman-6-yl-3-cyclopropyl-6-methyl-phenyl)-(2,2-difluoro-cyclopropoxy)acetic acid; (2-chroman-6-yl-3-cyclopropyl-4-methoxy-6-methyl-phenyl)-cyclopropoxy-acetic acid; 2-(2-chroman-6-yl-3-cyclopropyl-5-ethyl-6-methyl-phenyl)-2-(cyclopropoxy)acetic acid and a racemate, enantiomer, or diastereomer or pharmaceutically acceptable salt thereof.

EFFECT: invention also relates to the use of the compounds in the treatment or prevention of viral diseases, including HIV.

11 cl, 1 tbl, 63 ex