METHOD FOR PREPARING ALLAPININE Russian patent published in 2004 - IPC

FIELD: chemical-pharmaceutical industry, pharmacy.

SUBSTANCE: invention relates to a method for preparing a medicinal substance allapinine from vegetable raw using as anti-arrhythmic agent. Method for preparing allapinine involves extraction of north monkshood (wolfsbane, aconite) roots and rhizomes with 80% ethyl alcohol in two reactors wherein the first an aqueous-alcoholic extract from each reactor is fed to evaporation, the second, the third and the forth extracts are used for the first, the second and the third extraction of raw in other reactor, respectively. On the forth extraction 80% ethyl alcohol is fed into each reactor and pre-extraction of inert substances is carried out by treatment an aqueous vat residue with ethyl acetate, addition of hydrobromic acid solution to it and by extraction of alkaloids (as salts) with chloroform. Technical allapinine is isolated from chloroform extract by addition of ethyl alcohol at evaporation followed by recrystallization from methyl alcohol.

EFFECT: enhanced yield of allapinine, simplified technological process.

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