FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to preparing lappaconitine hydrobromide (allapinine) that is used as medicinal antiarrhythmic agent. Method involves extraction of monkshood (Aconitum septentrionale) roots and herb or monkshood (Aconitum leucostomum) roots and herb with 50-80% (by volume) an aqueous acetone. Impurities are removed from evaporated and acidified extract by single treatment with dichloroethane and alkaloids from an alkaline solution are isolated by 2-3-fold extraction with dichloroethane or ethyl acetate. EFFECT: simplified technology, high yield and purity of the end product. 1 tbl, 12 ex
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Authors
Dates
1998-12-20—Published
1996-03-19—Filed