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2 123 347

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IPC

(21) (22)

Application

96105244/14, 1996-03-19

(22)

Actual filing date

1996-03-19

(45)

Published

1998-12-20

(72)

Inventor

Junusov M.S.Tsyrlina E.M.Junusova S.G.Dokichev V.A.Savenko A.N.Istomin N.N.Lishtakov A.I.Galjautdinov A.A.

(73)

Holder

Institut Organicheskoj Khimii Ufimskogo Nauchnogo Tsentra Ran

METHOD OF LAPPACONITINE HYDROBROMIDE PREPARING Russian patent published in 1998 - IPC

Abstract RU 2123347 C1

FIELD: chemical-pharmaceutical industry. SUBSTANCE: invention relates to preparing lappaconitine hydrobromide (allapinine) that is used as medicinal antiarrhythmic agent. Method involves extraction of monkshood (Aconitum septentrionale) roots and herb or monkshood (Aconitum leucostomum) roots and herb with 50-80% (by volume) an aqueous acetone. Impurities are removed from evaporated and acidified extract by single treatment with dichloroethane and alkaloids from an alkaline solution are isolated by 2-3-fold extraction with dichloroethane or ethyl acetate. EFFECT: simplified technology, high yield and purity of the end product. 1 tbl, 12 ex

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RU 2 123 347 C1

Authors

Junusov M.S.

Tsyrlina E.M.

Junusova S.G.

Dokichev V.A.

Savenko A.N.

Istomin N.N.

Lishtakov A.I.

Galjautdinov A.A.

Dates

1998-12-20—Published

1996-03-19—Filed