FIELD: pharmaceuticals.
SUBSTANCE: invention relates to chemical and pharmaceutical industry and it is a process for preparing lappaconitine hydrobromide by extracting ground roots of Aconite septentrionale with a 70–80 % aqueous acetone solution with removal of non-alkaloid origin impurities from an evaporated and acidified extract by a single treatment with dichloroethane, alkalinization, releasing of alkaloids from the alkaline solution by extraction with dichloroethane, treatment of evaporated residue with an alcoholic solution of hydrobromic acid, with releasing lappaconitine hydrobromide, according to the invention, the ground raw material is premixed with water in a weight ratio of 1:(0.6–1) and mixed until a uniform state is obtained, an the raw material is being extracted in a continuous screw extractor.
EFFECT: invention provides shorter duration of extraction of roots Aconitum septentrionale to obtain lappaconitine hydrobromide, and to increase the yield of the target product.
1 cl, 1 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF LAPPACONITINE HYDROBROMIDE PREPARING | 1996 |
|
RU2123347C1 |
METHOD FOR PRODUCTION OF LAPPACONITINE HYDROBROMIDE AND LAPPACONITINE | 2016 |
|
RU2641967C1 |
METHOD FOR PREPARING LAPPACONITINE HYDROBROMIDE (VERSIONS) | 2012 |
|
RU2545799C2 |
ANTIARRHYTHMIC AGENT, METHOD FOR PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION BASED ON ANTIARRHYTHMIC AGENT | 2022 |
|
RU2825632C2 |
METHOD FOR PREPARING ALLAPININE | 2003 |
|
RU2238103C1 |
METHOD FOR OBTAINING LAPPACONINITY HYDROBROMIDE | 2017 |
|
RU2676304C1 |
METHOD OF PREPARING PREPARATIONS FROM VEGETABLE MEDICINAL RAW | 1999 |
|
RU2176919C2 |
METHOD OF INDUSTRIAL ALLAPININUM MANUFACTURING | 2012 |
|
RU2518742C2 |
METHOD OF OBTAINING HYDROBROMIDE LAPPACONITIN | 0 |
|
SU1196004A1 |
METHOD OF INCREASING CONTENT OF ALKALOID LAPPACONITINE IN PREPARED RHIZOMES OF ACONITUM SEPTENTRIONALE KOELLE | 2014 |
|
RU2580042C2 |
Authors
Dates
2018-03-07—Published
2016-12-22—Filed