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IPC

A61K36/714(2006-01-01)

A61K125/00(2006-01-01)

B01D11/02(2006-01-01)

(21) (22)

Application

2016132740, 2016-08-08

(24)

Start date

2016-08-08

(22)

Actual filing date

2016-08-08

(45)

Published

2018-01-23

(72)

Inventor

Yunusov Marat SabirovichMurinov Yurij IlichTsyrlina Elena MarkovnaYunusova Svetlana GrigorevnaGabbasov Tagir MazitovichSafiullin Rustam LutfullovichNazarov Aleksej MikhajlovichArslanov Linar GumerovichKildibekov Timur Albertovich

(73)

Holder

Federalnoe Gosudarstvennoe Byudzhetnoe Uchrezhdenie Nauki Ufimskij Institut Khimii Rossijskoj Akademii Nauk Ran)Obshchestvo S Ogranichennoj Otvetstvennostyu Tekhnokhimsintez"

METHOD FOR PRODUCTION OF LAPPACONITINE HYDROBROMIDE AND LAPPACONITINE Russian patent published in 2018 - IPC A61K36/714 A61K125/00 B01D11/02

Abstract RU 2641967 C1

FIELD: pharmacology.

SUBSTANCE: method for production of lappaconitine hydrobromide and lappaconitine by extracting aconite roots with 70-80% by volume aqueous acetone, acetone distilling off from the extract, alkalizing, alkaloids extraction with an organic solvent and then distillation, while benzene or toluene are used as an organic solvent for alkaloids extraction from the alkaline solution, after solvent distillation, the residue is divided into parts, with one part of the residue treated with acetone or alcohol to release lappaconitine, the other part of the residue trested with ethanol and alcoholic solution of hydrobromic acid to release lappaconitine hydrobromide.

EFFECT: increased yield and reduced number of process stages.

5 ex

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RU 2 641 967 C1

Authors

Yunusov Marat Sabirovich

Murinov Yurij Ilich

Tsyrlina Elena Markovna

Yunusova Svetlana Grigorevna

Gabbasov Tagir Mazitovich

Safiullin Rustam Lutfullovich

Nazarov Aleksej Mikhajlovich

Arslanov Linar Gumerovich

Kildibekov Timur Albertovich

Dates

2018-01-23—Published

2016-08-08—Filed