FIELD: pharmacology.
SUBSTANCE: method for production of lappaconitine hydrobromide and lappaconitine by extracting aconite roots with 70-80% by volume aqueous acetone, acetone distilling off from the extract, alkalizing, alkaloids extraction with an organic solvent and then distillation, while benzene or toluene are used as an organic solvent for alkaloids extraction from the alkaline solution, after solvent distillation, the residue is divided into parts, with one part of the residue treated with acetone or alcohol to release lappaconitine, the other part of the residue trested with ethanol and alcoholic solution of hydrobromic acid to release lappaconitine hydrobromide.
EFFECT: increased yield and reduced number of process stages.
5 ex
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Authors
Dates
2018-01-23—Published
2016-08-08—Filed