FIELD: organic chemistry, chemical technology, pharmacy.
SUBSTANCE: invention relates to new biologically active phosphonate derivatives of aciclovir and describes phosphonate derivatives of 9-[(2-hydroxyethyloxy)methyl]guanine (ACV) of the general formula:
wherein R' and R'' represent alkyl, aryl or aralkyl. Also, invention describes a method for preparing phosphonate derivatives of aciclovir. Invention provides preparing new compounds eliciting the selective antiherpetic activity with effectiveness that exceeds effectiveness of ACV and effecting on strains of herpes simplex virus that are resistant to effect of ACV. Except for, the claimed compounds can be components of active substance in the pharmaceutical composition taken in the effective therapeutic dose for it using as a medicinal agent eliciting antiherpetic antiviral activity.
EFFECT: improved preparing method, valuable medicinal properties of compounds.
4 cl, 3 tbl, 6 ex
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