FIELD: pharmacology.
SUBSTANCE: invention relates to a 2-amino-5,6-difluoro-1-(beta-D-ribofuranosyl)-benzimidazole of formula (I) suitable for treatment of herpes, and a method for its preparation that can be used in the pharmaceutical industry:
(I).
The proposed method involves ortho-phenylenediamine condensing with bromocyanide, followed by bromohydrate removal with sodium carbonate and a reaction of obtained base transribosylation with uridine in the presence of catalytic amounts of uridine phosphorylase and purine nucleoside phosphorylase.
EFFECT: new effective anti-herpes virus compound is proposed, including that against variants of the virus resistant to the action of basic antiherpetic drugs, as well as a new effective method for obtaining.
3 cl, 3 ex, 4 dwg
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