Show metadata Hide metadata

(19)

(11)

2 265 610

(13)

(51)

IPC

(21) (22)

Application

2004111854/04, 2004-04-20

(24)

Start date

2004-04-20

(22)

Actual filing date

2004-04-20

(45)

Published

2005-12-10

(72)

Inventor

Galegov G.A.Andronova V.L.Gurskij G.V.Surovaja A.N.Grokhovskij S.L.

(73)

Holder

Gosudarstvennoe Uchrezhdenie Nauchno-Issledovatel'Skij Institut Virusologii Im. D.I. Ivanovskogo Rossijskoj Akademii Meditsinskikh NaukInstitut Molekuljarnoj Biologii Im. V.A. Ehngel'Gardta Rossijskoj Akademii Nauk

DIMERIC DERIVATIVE OF NETROPSIN - 15-LYS-BIS-NETROPSIN AND COMBINATIONS BASED ON THEREOF POSSESSING ANTI-HERPETIC ACTIVITY Russian patent published in 2005 - IPC

Abstract RU 2265610 C1

FIELD: organic chemistry, amino acids, virology.

SUBSTANCE: invention relates to a new compound representing dimeric derivative of netropsin, namely, 15-Lys-bis-netropsin: 4-[4-[4-[4-[α,ω-bis-[α,ω-bis-(α,ω)-dilysyllysyl)lysyl]lysyl]glycylglycyl]amino-1-pr-opylpyrrol-2-carboxamido]-1-propylpyrrol-2-carbonyl]glycylglycylglycylamino]-1-propylpyrrol-2-carboxamido]-2-(3-dimethylaminopropylaminocarbonyl)-1-pr-opylpyrrole trifluoroacetate possessing an anti-viral activity and its combinations with modified nucleosides or phosphonoacetic/phosphonoformic acid also. Represented combinations provides selectivity of anti-herpetic effect and to enhance anti-herpetic effect significantly as compared with each separately taken combining antiviral compounds.

EFFECT: improved and valuable antiviral activity of derivative.

3 cl, 3 tbl, 4 ex

Similar patents RU2265610C1

Title	Year	Author	Number
COMBINATIONS BASED ON NETROPSIN OR ITS BIS-DERIVATIVE ELICITING ANTI-HERPETIC ACTIVITY	2002	Galegov G.A. Andronova V.L. Gurskij G.V. Surovaja A.N. Grokhovskij S.L.	RU2240792C2
NETROPSIN DERIVATIVES HAVING ANTIVIRAL ACTIVITY	2008	Galegov Georgij Artem'Evich Andronova Valerija L'Vovna Gurskij Georgij Valerianovich Surovaja Anna Nikitichna Grokhovskij Sergej L'Vovich	RU2394838C2
2-AMINO-5,6-DIFLUOR-1-(BETA-D-RIBOFURANOSYL)-BENZIMIDAZOLE, METHOD FOR PRODUCTION AND ANTIVIRAL ACTIVITY IN TERMS OF HERPES SIMPLEX VIRUS TYPE I	2016	Konstantinova Irina Dmitrievna Kharitonova Mariya Igorevna Miroshnikov Anatolij Ivanovich Kotovskaya Svetlana Konstantinovna Charushin Valerij Nikolaevich Galegov Georgij Artemevich Andronova Valeriya Lvovna	RU2629670C2
(3-HYDROXY-1-ADAMANTYL-)-1-ETHYLAMINE HYDROCHLORIDE AS 1-TYPE HERPES SIMPLEX VIRUS INHIBITOR	2001	Moiseev Igor' Konstantinovich Makarova Nadezhda Viktorovna Pozdnjakov Viktor Viktorovich Galegov Georgij Artem'Evich Andronova Valerija L'Vovna	RU2269338C1
-4-[6-(PURINE-6-YLAMINO)HEXANOYL]-3,4-DIHYDRO-3-METHYL-7,8-DIFLUOR-2H-[1,4]BENZOXAZINE AND (3R)-4-[6-(PURINE-6-YLAMINO)HEXANOYL]-3,4-DIHYDRO-3-METHYL-7,8-DIFLUOR-2H-[1,4]BENZOXAZINE WITH ANTIVIRAL ACTIVITY	2016	Musiyak Vera Vasilevna Galegov Georgij Artemevich Andronova Valeriya Lvovna Krasnov Viktor Pavlovich Levit Galina Lvovna Gruzdev Dmitrij Andreevich Chulakov Evgenij Nikolaevich Charushin Valerij Nikolaevich	RU2644351C1
3-BUTYLTHIO-1-(BETA-D-2-DEOXYRIBOFURANOSYL)-5-PHENYL-(4H)-1,2,4-TRIAZOLE, SYNTHESIS, ANTI-HERPES VIRUS ACTION	2023	Konstantinova Irina Dmitrievna Fateev Ilya Vladimirovich Andronova Valeriya Lvovna Esipov Roman Stanislavovich Miroshnikov Anatolij Ivanovich Sasmakov Sobirdzhan Anarmatovich Azimova Shakhnoz Sadykovna Abdurakhmanov Zhaloliddin Mirdzhamilevich Ziyaev Abdukhakim Anvarovich Dolimov Khaetzhon Khakimzhon Ugli	RU2815137C1
4-((Z)-4'-HYDROXYBUTENE-2'-YL)-2-R-6-FURYL-1,2,4-TRIAZOLO[5,1-c][1,2,4]TRIAZINE-7-ONS	2008	Chupakhin Oleg Nikolaevich Rusinov Vladimir Leonidovich Ulomskij Evgenij Nartsissovich Charushin Valerij Nikolaevich Shestakova Tat'Jana Sergeevna Deev Sergej Leonidovich Rusinova Larisa Ivanovna Andronova Valerija L'Vovna Galegov Georgij Artem'Evich Karpenko Inna Leonidovna Jas'Ko Maksim Vladimirovich Kukhanova Marina Konstantinovna	RU2376307C1
4,6-DI(3,12-DIAZA-6,9-DIAZONIADISPIRO[5,2,5,2]HEXADECAN-1-YL)-2-METHYL-5-NITROPYRIMIDINE TETRACHLORIDE HYDROCHLORIDE HEXAHYDARATE FOR TREATING HERPETIC INFECTION, PHARMACEUTICAL COMPOSITION FOR LOCAL APPLICATION	2014	Makarov Vadim Albertovich Monakhova Natalya Sergeevna Ryabova Olga Borisovna	RU2573977C9
PHOSPHONATE DERIVATIVES OF ACICLOVIR AND METHOD FOR THEIR PREPARING	2003	Galegov G.A. Andronova V.L. Skoblov Ju.S. Jas'Ko M.V. Kukhanova M.K. Karpenko I.L. Ivanov A.V.	RU2239638C2
COMPLEXES OF GERMANIUM WITH PURINE NITROGENOUS BASES, METHODS FOR PRODUCTION THEREOF AND MEDICINAL AGENTS CONTAINING SAID COMPLEXES	2012	Isaev Aleksandr Dmitrievich Ambrosov Igor' Valer'Evich Manasherov Tamaz Omarovich Matelo Svetlana Konstantinovna	RU2487878C1

RU 2 265 610 C1

Authors

Galegov G.A.

Andronova V.L.

Gurskij G.V.

Surovaja A.N.

Grokhovskij S.L.

Dates

2005-12-10—Published

2004-04-20—Filed