FIELD: biochemistry.
SUBSTANCE: invention relates to the field of biochemistry, in particular to a chimeric antigen receptor for binding with a tyrosine-kinase growth factor receptor. An expression vector, a genetically engineered cytotoxic cell, and a pharmaceutical composition are disclosed. A method for producing a chimeric antigen receptor and a method for the treatment of cancer are also disclosed.
EFFECT: invention allows for the effective treatment of a disease associated with a tyrosine-kinase growth factor receptor.
23 cl, 6 dwg, 3 tbl, 7 ex
| Title |
Year |
Author |
Number |
| CONDITIONALLY ACTIVE CHIMERIC ANTIGENIC RECEPTORS FOR MODIFIED T CELLS |
2016 |
|
RU2759957C2 |
| CHIMERIC ANTIGEN RECEPTORS WITH MUTATED CD28 COSTIMULATION DOMAINS |
2018 |
|
RU2800922C2 |
| METHODS AND FORMULATIONS FOR PRODUCING LYMPHOCYTES AND FOR CONTROLLED INCREASE THEREOF |
2017 |
- Frost Gregori Yan
- Onuffer Dzhejms Dzhozef
- Gujbinga Gyabe Kh.
- Kundu Anirban
|
RU2755059C2 |
| PHARMACEUTICAL COMPOSITION POSSESSING ANTITUMOUR EFFECT, AND METHOD FOR REDUCING PD-L1 INHIBITING EFFECT ON HUMAN T-CELLS |
2016 |
|
RU2688692C2 |
| IMMUNE CELLS DEFECTIVE BY Suv39h1 |
2018 |
- Amigorena, Sebastyan
- Pyadzho, Elyane
- Gudo, Kristel
- Pache, Luidzha
- Almuzni, Zheneveva
- Niborski, Letitsiya
|
RU2784531C2 |
| MODIFIED CELLS WITH CHIMERIC ANTIGEN RECEPTOR FOR TREATING CANCER EXPRESSING CLDN6 |
2020 |
- Sahin, Ugur
- Oehm, Petra
- Rengstl, Benjamin
- Reinhard, Katharina
- Michel, Kristina
|
RU2826058C2 |
| MODIFIED MONOCYTES/MACROPHAGES EXPRESSING CHIMERIC ANTIGEN RECEPTORS AND THEIR APPLICATIONS |
2016 |
- Gill, Saar
- Klichinsky, Michael
- June, Carl H.
|
RU2766690C2 |
| CHIMERIC ANTIGENIC RECEPTORS WITH MND-PROMOTER |
2015 |
- Morgan, Richard
- Friedman, Kevin
- Ryu, Byoung
|
RU2708311C2 |
| LABELED CHIMERIC EFFECTOR MOLECULES AND RECEPTORS THEREOF |
2014 |
- Riddell, Stanley, R.
- Liu, Lingfeng
|
RU2729463C2 |
| CHIMERIC ANTIGENIC RECEPTORS WITH MND PROMOTER |
2015 |
- Morgan, Richard
- Friedman, Kevin
- Ryu, Byoung
|
RU2799573C2 |
