FIELD: biotechnology, medicine, immunology.
SUBSTANCE: invention relates to recombinant vaccine against HIV-1 that represents a combination of immunogens as micelle-like particles comprising recombinant plasmid DNA pcDNA-TCI covered by conjugate spermidine-polyglucine with recombinant protein TBI comprising conservative T- and B-cellular virus-neutralizing epitopes in the stabilizing system. In immunization using this created vaccine production of specific antibodies possessing the virus-neutralizing activity is induced as well specific cytotoxic immune response also.
EFFECT: valuable medicinal properties of vaccine.
1 tbl, 5 dwg, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| CONJUGATE OF THE RECEPTOR-BINDING DOMAIN (RBD) PROTEIN OF SARS-CoV-2 SURFACE GLYCOPROTEIN S WITH POLYGLUCIN-SPERMIDINE (PGS) POLYMER AND VACCINE COMPLEX AGAINST CORONAVIRUS INFECTION COVID-19 BASED ON THE SPECIFIED CONJUGATE AND PLASMID DNA PVAX-RBD | 2022 |
|
RU2781294C1 |
| VACCINE AGAINST VIRAL INFECTIONS | 2000 |
|
RU2217162C2 |
| SUPPOSITORY FOR IMMUNOPROPHYLAXIS OF VIRAL INFECTIONS | 2004 |
|
RU2296560C2 |
| RECOMBINANT CHIMERICAL nTBI POLYPEPTIDE-IMMUNOGEN WITH ABILITY TO INDUCE NEUTRALIZING ANTIBODIES TO TYPE 1 HUMAN IMMUNODEFICIENCY VIRUS AND INTENDED FOR USE AS COMPONENT OF VACCINE AGAINST HIV-1 | 2016 |
|
RU2642258C1 |
| RECOMBINANT PLASMID DNA PCDNA-TCI PROVIDING EXPRESSION OF ARTIFICIAL GENE TCI IN EUCARYOTIC CELLS AND RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERITIDIS E-23 PC-DNA-TCI AS CANDIDATE FOR CONSTRUCTION OF LIVE DNA-VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS | 2003 |
|
RU2248396C2 |
| RECOMBINANT PLASMID DNA PTBI-HBSAG COMPRISING CHIMERIC GENE TBI-HBSAG UNDER CONTROL OF SMALLPOX VACCINE PROMOTER P7,5K AND STRAIN OF RECOMBINANT SMALLPOX VACCINE INDUCING IMMUNE RESPONSE AGAINST HIV AND HUMAN HEPATITIS B IN ANIMAL BODY | 2001 |
|
RU2194075C2 |
| PLASMID pVAX-RBD DNA MATRIX OF mRNA-RBD MOLECULES, OBTAINED USING THE pVAX - RBD DNA MATRIX, PROVIDING THE SYNTHESIS AND SECRETION OF THE RBD PROTEIN SARS-CoV 2 IN MAMMALIAN CELLS AND A COMPLEX IN THE FORM OF NANOPARTICLES CONTAINING mRNA-RBD MOLECULES THAT INDUCE SARS-CoV-SPECIFIC ANTIBODIES WITH VIRAL NEUTRALIZING ACTIVITY | 2021 |
|
RU2754230C1 |
| RECOMBINANT ATTENUATED STRAIN OF BACTERIUM SALMONELLA ENTERIDITIS E-23/PGEX-2T-TBI AS CANDIDATE FOR CONSTRUCTION OF LIVE VACCINE AGAINST HUMAN IMMUNODEFICIENCY VIRUS | 2002 |
|
RU2237089C2 |
| ARTIFICIAL YkuJ-MPER GENE ENCODING YkuJ-MPER RECOMBINANT PROTEIN-IMMUNOGEN, pET21a-YkuJ-MPER RECOMBINANT PLASMID DNA, PROVIDING EXPRESSION OF ARTIFICIAL YkuJ-MPER GENE, AND YkuJ-MPER RECOMBINANT PROTEIN-IMMUNOGEN, WHICH IS CARRIER OF MEMBRANE-PROXIMAL AREA OF HIV-1 AND INTENDED FOR INDUCTION IN BROADLY NEUTRALIZING ANTIBODIES | 2017 |
|
RU2679076C1 |
| ARTIFICIAL MYCOBACTERIAL PARTICLES AND ANTI-TUBERCULOSIS VACCINE COMPOSITION BASED ON THEREOF | 2003 |
|
RU2242245C2 |
