NEW DERIVATIVES AND ANALOGUES OF 3-ARYLPROPIONIC ACID Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, endocrinology, pharmacy.

SUBSTANCE: invention relates to new derivatives and analogues of 3-arylpropionic acid of the general formula (I) ,

their seteroisomers, optical isomers and racemates and to their pharmaceutically acceptable salts. The group A in the indicated formula (I) is at meta- or para-position and it represents

wherein R represents hydrogen atom; -OR^a wherein R^a represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR^aR^b wherein R^a and R^b are similar or different and represent hydrogen atom, alkyl, phenyl, alkylphenyl, cyano-group; R¹ represents alkyl, cyano-group; -OR^e wherein R^e represents alkyl, phenyl or alkylphenyl; -O-[CH₂]_m-OR^f wherein R^f represents alkyl; m represents a whole number 1-2; -SR^d wherein R^d represents alkyl or phenyl; -SO₂OR^a wherein R^a represents alkyl, phenyl or alkylphenyl; -COOR^d wherein R^d represents alkyl; R² represents hydrogen atom or alkyl; R³ and R⁴ are similar or different and each represents hydrogen atom or alkyl; n represents a whole number 1-3; D is at ortho-, meta- or position and represents -OSO₂R^d wherein R^d represents alkyl, phenyl or alkylphenyl; -OCONR^fR^a wherein R^f and R^a represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR^cCOOR^d wherein R^c represents hydrogen atom or alkyl, and R^d represents alkyl, phenyl or alkylphenyl; -NR^cCOR^a wherein R^c represents hydrogen atom or alkyl, and R^a represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR^cR^d wherein R^c and R^d represent hydrogen atom, alkyl, phenyl or alkylphenyl; -NR^cSO₂R^d wherein R^c represents hydrogen atom or alkyl, and R^d represents alkyl, phenyl or alkylphenyl; -NR^cCONR^aR^k wherein R^c represents hydrogen atom, R^a and R^k are similar or different and each represents hydrogen atom, alkyl, phenyl or alkylphenyl; -NR^cCSNR^aR^k wherein R^c represents hydrogen atom, R^a and R^k are similar or different and each represents hydrogen atom, phenyl or alkylphenyl; -SO₂R^d wherein R^d represents alkyl, phenyl or alkylphenyl; -SR^c wherein R^c represents alkyl, phenyl or alkylphenyl; -SO₂OR^a wherein R^a represents alkyl, phenyl or alkylphenyl; -CN; -CONR^cR^a wherein R^c represents hydrogen atom or alkyl and R^a represents hydrogen atom or alkyl; D is at meta-position and represents -OR^f wherein R^f represents alkyl, or it represents hydrogen atom; D'' is at ortho-, meta- or para-position and represents hydrogen atom wherein indicated alkyl a direct or branched alkyl group comprising from 1 to 6 carbon atoms, either cyclic alkyl comprising from 3 to 6 carbon atoms being indicated alkyl can be substituted with one or more group taken among alkyl, alkoxy-, halogen atom or phenyl wherein indicated phenyl can be substituted with one or more group taken among alkyl, alkoxy-, nitro-, thiol or halogen atom. Also, invention relates to a method for their preparing, pharmaceutical preparations comprising thereof and applying these compounds in clinical states associated with resistance to insulin.

EFFECT: valuable medicinal properties of compounds.

41 cl, 109 ex