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2 245 335

(13)

(51)

IPC

(21) (22)

Application

2001101559/04, 1999-06-16

(24)

Start date

1999-06-16

(22)

Actual filing date

1999-06-16

(45)

Published

2005-01-27

(72)

Inventor

Littlfild Brjus A.Palm MonikaSeletskij Boris M.Taul Mjurrej Dzh.Ju Melvin Dzh.Zeng Vandzun

(73)

Holder

Ehjsaj Ko., Ltd.

MACROCYCLIC COMPOUND AND METHOD FOR IDENTIFYING AGENT BASED ON THEREOF Russian patent published in 2005 - IPC

Abstract RU 2245335 C2

FIELD: organic chemistry, medicine, oncology.

SUBSTANCE: invention relates to new macrocyclic compounds of the formula: , wherein A, D, D¹, G, Z, Z¹, E, X, T, Q, Y, Y¹, J, J¹, U, U¹ and n have values given in the description. Also, invention relates to a method for identification of agents that induce the continuous mitotic block in cell after temporary exposition of cell with this agent. Compounds elicit anticancer and antimitotic (mitosis-blocking) activity. Invention provides preparing new macrocyclic compounds eliciting strong anticancer effect.

EFFECT: improved identifying method, valuable medicinal properties of compounds.

21 cl, 2 tbl, 501 ex

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RU 2 245 335 C2

Authors

Littlfild Brjus A.

Palm Monika

Seletskij Boris M.

Taul Mjurrej Dzh.

Ju Melvin Dzh.

Zeng Vandzun

Dates

2005-01-27—Published

1999-06-16—Filed