METHOD FOR PREPARING N-PHTHALIMIDOALKYLADAMANTANE OR ITS DERIVATIVES Russian patent published in 2005 - IPC

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to chemistry of adamantine derivatives, namely, to a method for preparing N-phthalimidoalkyladamantane or its derivatives of the general formula: wherein X means a single bond; R¹ means hydrogen atom (H); R means C₆H₅, C₆H₄COOC₂H₅; R¹ means CH₃; R means CH₃; R¹ means COOC₂H₅; R means CH₂CH₂SCH₃, (CH₂)₃CH₃; X means CH₂CH₂; R¹ = R means COOC₂H₅; X, R¹ mean ; R means COOC₂H₅ that represent important intermediate products in synthesis of biologically active substances. Method is carried out by adding corresponding N-phthalimidoalkyl or its derivative to a derivative of adamantine. 1,3-Dehydroadamantane is used as a derivative of adamantine, and the following compounds are used as N-phthalimidoalkyl or its derivative: N-benzylphthalimide, N-isopropylphthalimide, ethyl esters of N-phthalyl-D,L-methionine, N-phthalyl-D,L-norleucine, N-phthalyl-4-aminomethyl-1-benzoic acid, N-phthalyl-4-aminocyclohexane 1-carboxylic acid, 2-(N-phthalimido)-ethylmalonic acid ethyl ester. Process is carried out in the mole ratios of reagents = 1:(2-3), respectively, in inert solvent medium, at temperature 80-120^oC for 4-6 h.

EFFECT: improved preparing method, enhanced yield of end compounds.

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