FIELD: chemistry.
SUBSTANCE: invention concerns chemistry of adamantane derivatives, particularly new method of obtaining N,N-dialkyl-substituted amides of adamantylalkylcarboxylic acids of the general formula
which can be of interest as semiproducts in synthesis of some bioactive substances with antivirus effect. Method involves interaction of adamantane derivative with carboxylic acid dialkylamide, where 1,3-dehydroadamantane is used as adamantane derivative, and N,N-dimethylacetamide, N,N-diethylacetamide, N-acethylpiperidine, N-propionylpiperidine, N-(2-methyl)propionylpiperidine are used as carboxylic acid dialkylamides, and process runs at reagent mol ratio of 1:2-3 respectively, in original carboxylic acid dialkylamide medium at 120-130°C for 5-6 hours.
EFFECT: alternative method of obtaining compounds of the claimed structural formula, with omitted stage of obtaining adamantylalkylcarboxylic acids.
5 ex
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Authors
Dates
2009-03-10—Published
2007-05-02—Filed