METHOD OF OBTAINING DIALKYLAMIDES OF 3-BROME-1-ADAMANTILALKANCARBON ACIDS Russian patent published in 2009 - IPC C07C231/12 C07C233/12 C07D211/38 

Abstract RU 2344122 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention concerns chemistry of adamantane derivatives, namely to a new method of obtaining of dialkylamides of 3-brome-1-adamantilalkancarbon acids of the general formula:

R1,R2=H:R3=N(C2H5)2

R1, R2=CH3:R3=N(C2H5)2

which can be of interest as semiproducts in synthesis of some biologically active substances possessing antiviral activity. Method lies in interaction of 1,3-dehydroadamantane with dialkylamides of α-bromalkancarbon acids from the row: diethylamide of α-bromacetic acid, piperidide of α-brompropionic acid, diethylamide of α-bromo-isobutyric acid at mole ratio of reagents peer accordingly 1:3-4, in the environment of the initial dialkylamides of α-bromalkancarbon acids, at temperature of 80-90°C within 4-6 hours.

EFFECT: obtaining of bonds of declared structural formula, excluding reception stage adamantilealkanecarbon acids.

3 ex

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RU 2 344 122 C1

Authors

Butov Gennadij Mikhajlovich

Mokhov Vladimir Mikhajlovich

D'Jakonov Sergej Vladimirovich

Dates

2009-01-20Published

2007-07-09Filed