METHOD FOR PREPARING PHARMACEUTICAL COMPOSITION ELICITING ANTI-INFLAMMATORY AND ANALGETIC ACTIVITY AND COMPRISING AMORPHOUS NITROESTERS Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to a method for preparing a pharmaceutical composition eliciting anti-inflammatory and analgetic activity for oral administration and containing compound of the formula (I): A-X₁-NO₂ wherein A and X₁ are given in cl. 1 of the invention claim and representing in the amorphous state or partially amorphous state. Method involves the following steps: stirring compound of the formula (I) with at least one filling agent that is able to confer the amorphous state to obtained mixture wherein this filling agent is taken among group consisting of (C₅-C₆)-polyalcohols, mono- and disaccharides and their derivatives, oligosaccharides comprising from 3 to 10 monosaccharide units, polysaccharides, their derivatives involving their salts, cyclodextrins and their derivatives, noncyclic derivatives of β-cyclodextrin, polymers and copolymers based on vinyl monomeric links, and/or comprising the carboxyl function, or methacrylic monomers wherein the mass ratio between amount of compound of the formula (I) and the amount of at least one filling agent is in the range = (1:20)-(1:0.5), and providing the amorphous state of obtained mixture by combined grinding, stirring, spraying drying and lyophilization. Also, invention relates to a pharmaceutical composition eliciting an anti-inflammatory and analgetic activity. Invention provides preparing a pharmaceutical composition for oral administration and medicinal agents based on thereof for treatment of inflammatory diseases.

EFFECT: improved preparing method, valuable medicinal properties of composition.

10 cl, 1 tbl, 10 ex