NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND ANTICANCER AGENT Russian patent published in 2005 - IPC

Abstract RU 2248969 C2

FIELD: organic chemistry, heterocyclic compounds, medicine, pharmacy.

SUBSTANCE: invention relates to nitrogen-containing heterocyclic derivatives of the formula (I): A-B-D-E (I) wherein A means 5- or 6-membered heteroaryl comprising one or two nitrogen atoms in ring; B means ethenylene; D mean phenylene; E means group -N(COR)-SO₂-G wherein G means phenyl; R means 5- or 6-membered heteroaryl or heteroarylmethyl comprising one or two nitrogen atoms in ring, or group -(CH₂)_n-N(R⁵)R⁶ wherein n means a whole number from 1 to 5; R⁵ and R⁶ are similar or different and mean: hydrogen atom, (C₁-C₆)-alkyl, hydroxyalkyl, aminoalkyl; or R⁵ and R⁶ in common with nitrogen atom can form 5-7-membered cyclic amino-group -N(R⁵)R⁶ that can comprise, except for nitrogen atom, also oxygen, sulfur or nitrogen atom as a component forming the ring, or their N-oxides. Compounds of the formula (I) elicit anticancer activity and can be used in medicine.

EFFECT: valuable medicinal properties of compounds.

10 cl, 1 tbl, 24 ex

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RU 2 248 969 C2

Authors

Suzuki Tosijuki

Aoki Tomiesi

Dates

2005-03-27—Published

2000-12-13—Filed