FIELD: biotechnology.
SUBSTANCE: claimed method includes conjugation of capsule polysaccharides A and C with synthesized peptide outer membrane protein fragments of meningococcus of serogroup B, having frank protective activity against to meningococcus serogroups A, B and C. capsule polysaccharides of meningococcus serogroups A and C are used in preparation of bivalent vaccine B/A and B/C, respectively. Said polysaccharide are oxidized before conjugation.
EFFECT: vaccine with improver protective activity against to meningococcus infection of various serogroups.
3 cl, 1 tbl, 7 dwg
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Authors
Dates
2005-04-20—Published
2003-06-04—Filed