ALPHA4-INTEGRINE MEDIATED CELL ADHESION INHIBITORS Russian patent published in 2005 - IPC

FIELD: biochemistry, medicine.

SUBSTANCE: invention relates to phenylalanine derivatives of formula I , wherein X¹ and X² are halogen; Q is CH₂ or -(CH₂)-; Y is C1-C6-alkyl; CO₂R is carboxylic group which may be transetherified; or pharmaceutically acceptable salts thereof. Pharmaceutical composition is disclosed having inhibition activity against α4-integrine mediated cell adhesion. Said composition includes therapeutically effective amount of claimed derivative or pharmaceutically acceptable salt thereof in mixture with pharmaceutically acceptable carrier or diluent. Derivatives of present invention or pharmaceutically acceptable salt thereof are useful as active therapeutic agent inhibiting α4-integrine mediated cell adhesion. Also disclosed are application of phenylalanine derivatives of formula I or pharmaceutically acceptable salts thereof to produce drug for treatment of diseases associated with α4-integrine mediated cell adhesion. Method for treatment or prophylaxis diseases associated with α4-integrine mediated cell adhesion includes administrating to patient effective amount of phenylalanine derivatives of formula I or pharmaceutically acceptable salt thereof. Further methods (variants) for production of target derivatives are disclosed.

EFFECT: α4-integrine inhibiting phenylalanine derivatives.

20 cl, 42 ex