FIELD: organic chemistry, pharmaceutical industry, medicine.
SUBSTANCE: invention relates to new derivatives of S-substituted N-1-[(hetero)aryl]alkyl-N'-1-[(hetero)aryl]alkylisothioureas of general formula I
in form of free base and salts with pharmaceutically accepted acids, as well as racemate, individual optical isomers or mixture thereof. In formula R1, R2, R3, R4, Y and Z are as described in specification. Compounds of present invention are capable to potentiate (positively modulate) AMPA/KA glutamate receptors and simultaneously to block transmembrane currents induced by activation of NMDA glutamate receptors. Also disclosed are method for production of said compounds, including optical isomers; pharmaceutical composition; method for investigation of glutamatergic system, and method for Alzheimer's disease, treatment; as well as method for extreme retentiveness of memory by administering of effective amount of claimed compounds.
EFFECT: new pharmaceutically active compounds for Alzheimer's disease treatment.
23 cl, 1 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DERIVATIVES OF N,S-SUBSTITUTED N'-1-[(HETERO)ARYL]-N'-[(HETERO)ARYL]- METHYLISOTHIOUREAS OR THEIR SALTS AND BASES, PHARMACEUTICAL COMPOSITION, METHOD FOR TREATMENT AND METHOD FOR STUDY OF GLUTAMATERGIC SYSTEM | 2001 |
|
RU2223952C2 |
| N, N', N', - TRISUBSTITUTED ISOSELENOUREAS | 2010 |
|
RU2434852C1 |
| N,N'-SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES WITH PHARMACOLOGICAL EFFECT, PHARMACOLOGICAL COMPOSITIONS ON THEIR BASE, AND APPLICATION METHOD | 2006 |
|
RU2333211C1 |
| DERIVATIVES OF HYDROGENATED PYRIDO[4,3-B]INDOLES, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF PATIENT TREATMENT | 1995 |
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| SUBSTITUTED PHENYL METHANONE DERIVATIVES | 2007 |
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| 4,4'-BIPHENYLAMIDE DERIVATIVES SHOWING PHARMACOLOGICAL ACTIVITY, AND BASED DRUG PREPARATIONS | 2011 |
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| SPIROPYRAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR MODULATION OF OPIOID RECEPTOR AND METHOD FOR TREATMENT USING SUCH COMPOUNDS | 2002 |
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RU2299883C2 |
| COMPOUNDS BEING ACTIVE AT A NEW SITE UPON RECEPTOR-OPERATED CALCIUM CANALS APPLIED FOR TREATING NEUROLOGICAL DISORDERS | 1996 |
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| DIAZASPIROPIPERIDINE DERIVATIVES | 2004 |
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| DIAZASPIROPIPERIDINE DERIVATIVES AS GLYCINE CARRIER 1 AND GLYCINE CARRIER 2 INHIBITORS | 2004 |
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