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2 456 266

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IPC

C07C237/20(2006-01-01)

A61K31/165(2006-01-01)

A61P25/00(2006-01-01)

(21) (22)

Application

2011113045/15, 2011-04-06

(24)

Start date

2011-04-06

(22)

Actual filing date

2011-04-06

(45)

Published

2012-07-20

(72)

Inventor

Zefirov Nikolaj SerafimovichPaljulin Vladimir AleksandrovichLavrov Mstislav IgorevichMorozov Aleksej SergeevichLapteva Vera LeonidovnaZapol'Skij Maksim Ehduardovich

(73)

Holder

Zapol'Skij Maksim Ehduardovich

4,4'-BIPHENYLAMIDE DERIVATIVES SHOWING PHARMACOLOGICAL ACTIVITY, AND BASED DRUG PREPARATIONS Russian patent published in 2012 - IPC C07C237/20 A61K31/165 A61P25/00

Abstract RU 2456266 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to chemical-pharmaceutical industry, and concerns new 4,4'-biphenylamide derivatives showing pharmacological activity and being applicable for treating Alzheimer's disease, Parkinson's disease and other neurodegenerative pathologies. Besides, the present invention refers to drug preparations containing said compounds. There are offered the 4,4'-biphenylamide derivatives showing pharmacological activity of general formula 1: wherein: HY in what follows represents a pharmaceutically acceptable acid; R₁ R₁' can be identical or different and each independently represents H, C₁-C₆ alkyl, C₁-C₁₀ alkoxy, halogen, a nitro-group, an amino-group, nitril, acyl, aryl; R₃, R₃', R₄, R₄', R₅, R₅', R₆ and R₆' can be identical or different and each independently represents H, C₁-C₆ alkyl, C₁-C₁₀ alkoxy; R₂ as a whole is presented by general formulas (1.1a), (1.2a), (1.3a), (1.4a), (1.5a).

EFFECT: invention allows extending the range of products applicable as new effective allosteric AMPA receptor modulators.

21 cl, 11 ex

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RU 2 456 266 C1

Authors

Zefirov Nikolaj Serafimovich

Paljulin Vladimir Aleksandrovich

Lavrov Mstislav Igorevich

Morozov Aleksej Sergeevich

Lapteva Vera Leonidovna

Zapol'Skij Maksim Ehduardovich

Dates

2012-07-20—Published

2011-04-06—Filed