FIELD: medicine; pharmaceuticals.
SUBSTANCE: disclosed are compounds of formula 2 , where n=1-10, and R is a fragment of vancomycin, eremomycin or teicoplanin aglycone. Method for preparing compounds of formula 2 comprises conducting acylation reaction 11-O-(ω-aminoalkylcarbamoyl)azithromycin (6) with glycopeptide antibiotic (eremomycin or vancomycin, or teicoplanin aglycone) in presence of a condensing agent.
EFFECT: invention relates to novel derivatives of azithromycin and a method for production thereof, which can be used in pharmaceutical industry and medicine.
2 cl, 4 dwg, 2 ex, 2 tbl
Title | Year | Author | Number |
---|---|---|---|
CHIMERIC ANTIBIOTICS BASED ON GLYCOPEPTIDES AND 11,12-CYCLIC CARBONATE AZITHROMYCIN AND METHOD FOR PRODUCTION THEREOF | 2014 |
|
RU2570425C1 |
NOVEL DERIVATIVES OF EREMOMYCIN AND USE THEREOF FOR TREATING BACTERIAL INFECTIONS | 2019 |
|
RU2708628C1 |
NEW SEMI-SYNTHETIC EREMOMYCINE DERIVATIVE AND ITS APPLICATION | 2016 |
|
RU2641912C1 |
N-(GUANIDINOALKYL) AMIDES OF EREMOMYCIN AND THEIR USE FOR TREATING BACTERIAL INFECTIONS | 2022 |
|
RU2815029C1 |
NEW DERIVATIVES OF EREMOMYCIN AMIDE AND APPLICATION THEREOF FOR TREATING BACTERIAL INFECTIONS | 2020 |
|
RU2751334C1 |
SORBENT FOR RESOLUTION OF OPTICAL ISOMERS AND A METHOD FOR PREPARATION THEREOF | 2004 |
|
RU2255802C1 |
AMYCOLATOPSIS ORIENTALIS STRAIN - DIMETHYLVANCOMYCIN ANTIBIOTIC PRODUCER AND METHOD FOR ANTIBIOTIC PRODUCTION | 2016 |
|
RU2633511C1 |
STRAIN AMYCOLATOPSIS ORIENTALIS SUBSPECIES EREMOMYCINI VKPM-S892 - A PRODUCER OF ANTIBIOTIC EREMOMYCIN AND A METHOD OF ANTIBIOTIC EREMOMYCIN PRODUCING | 1997 |
|
RU2110578C1 |
ANTIBIOTIC EREMOMYCIN AND METHOD OF ITS PREPARING | 1981 |
|
SU1475150A1 |
AMYCOLATOPSIS UMGENIENSIS STRAIN - PRODUCER OF UREMYCIN ANTIBIOTIC | 2018 |
|
RU2689699C1 |
Authors
Dates
2016-03-27—Published
2014-12-22—Filed