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2 578 604

(13)

(51)

IPC

A61K38/14(2006-01-01)

C07H17/08(2006-01-01)

A61P31/04(2006-01-01)

(21) (22)

Application

2014151833/04, 2014-12-22

(24)

Start date

2014-12-22

(22)

Actual filing date

2014-12-22

(45)

Published

2016-03-27

(72)

Inventor

Tevjashova Anna NikolaevnaPreobrazhenskaja Marija NikolaevnaPrintsevskaja Svetlana SergeevnaMirchink Elena PavlovnaIsakova Elena Borisovna

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Nauchnoe Uchrezhdenie Institut Po Izyskaniju Novykh Antibiotikov Imeni G.F. Gauze"

CHIMERIC ANTIBIOTICS BASED ON AZITHROMYCIN AND GLYCOPEPTIDE ANTIBIOTICS, HAVING ANTIBACTERIAL ACTIVITY AND SYNTHESIS METHOD THEREOF Russian patent published in 2016 - IPC A61K38/14 C07H17/08 A61P31/04

Abstract RU 2578604 C1

FIELD: medicine; pharmaceuticals.

SUBSTANCE: disclosed are compounds of formula 2 , where n=1-10, and R is a fragment of vancomycin, eremomycin or teicoplanin aglycone. Method for preparing compounds of formula 2 comprises conducting acylation reaction 11-O-(ω-aminoalkylcarbamoyl)azithromycin (6) with glycopeptide antibiotic (eremomycin or vancomycin, or teicoplanin aglycone) in presence of a condensing agent.

EFFECT: invention relates to novel derivatives of azithromycin and a method for production thereof, which can be used in pharmaceutical industry and medicine.

2 cl, 4 dwg, 2 ex, 2 tbl

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RU 2 578 604 C1

Authors

Tevjashova Anna Nikolaevna

Preobrazhenskaja Marija Nikolaevna

Printsevskaja Svetlana Sergeevna

Mirchink Elena Pavlovna

Isakova Elena Borisovna

Dates

2016-03-27—Published

2014-12-22—Filed